2003
Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity
SHEPERTYCKY M, AL‐BARRAK M, KRYGER M. Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity. Sleep And Biological Rhythms 2003, 1: 15-28. DOI: 10.1046/j.1446-9235.2003.00003.x.Peer-Reviewed Original ResearchObstructive sleep apnea syndromeSevere cardiovascular outcomesCongestive heart failureIschemic heart diseaseCardiovascular morbidityHeart failureCardiovascular outcomesPulmonary hypertensionSystemic hypertensionHeart diseaseCardiac arrhythmiasContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentOngoing population-based studyLarge ongoing trialsUntreated OSAS patientsIndependent risk factorDevelopment of hypertensionEpisodes of apneaSleep apnea syndromePopulation-based studyEffect of treatmentNocturnal hypoxemiaOSA patientsOSAS patients
1999
Clinical presentations of obstructive sleep apnea syndrome
Skomro R, Kryger M. Clinical presentations of obstructive sleep apnea syndrome. Progress In Cardiovascular Diseases 1999, 41: 331-340. PMID: 10406327, DOI: 10.1053/pcad.1999.0410331.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeQuality of lifeApnea syndromeClinical presentationTreatment of OSASClinical practiceBlood pressure controlIschemic heart diseaseHealth care professionalsMiddle-aged adultsCardiovascular morbidityPulmonary hypertensionMajor sequelaeUnderrecognized disorderCardiorespiratory failureDaytime somnolenceUpper airwayPrompt evaluationHeart diseaseRisk factorsClinical impressionNeurocognitive complaintsCare professionalsPressure control
1991
Central sleep apnoea in congenital muscular dystrophy.
Kryger M, Steljes D, Yee W, Mate E, Smith S, Mahowald M. Central sleep apnoea in congenital muscular dystrophy. Journal Of Neurology Neurosurgery & Psychiatry 1991, 54: 710. PMID: 1940943, PMCID: PMC1014476, DOI: 10.1136/jnnp.54.8.710.Peer-Reviewed Original ResearchConceptsCentral sleep apnoeaSleep-disordered breathingCongenital muscular dystrophyMorning headachesSleep apnoeaNocturnal seizuresCongestive heart failureMuscular dystrophyPulmonary hypertensionClinical weaknessHeart failureExcessive daytimeNeuromuscular syndromeRespiratory dysfunctionNeuromuscular disordersApnoeaHeadacheSeizuresSymptomsBreathingDystrophyHypertensionDysfunctionSyndrome
1987
Hypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease
Kryger M, Rogelio P, Conway W, Roth T, Anthonisen N, George C. Hypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 216-223. PMID: 3629083, DOI: 10.1093/sleep/10.3.216.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseBlue bloatersPink puffersSleep hypoxemiaPulmonary diseaseO2 desaturationHypoxemic chronic obstructive pulmonary diseaseNocturnal Oxygen Therapy TrialBetter lung functionArterial blood gasesWide clinical spectrumHypercapnic patientsSame PaO2Sleep oxygenationSleep SaO2Airflow obstructionHypoxemic patientsPulmonary hypertensionCOPD populationHypercapnic groupMost patientsNormocapnic patientsLung functionBlood gases
1981
Sleep Disorders in Chronic Airflow Obstruction
Fleetham J, Kryger M. Sleep Disorders in Chronic Airflow Obstruction. Medical Clinics Of North America 1981, 65: 549-561. PMID: 7017303, DOI: 10.1016/s0025-7125(16)31513-9.Peer-Reviewed Original ResearchConceptsChronic airflow obstructionAirflow obstructionPulmonary hypertensionCardiac arrhythmiasLess rapid eye movement sleepRapid eye movement (REM) sleepSecondary pulmonary hypertensionNocturnal oxygen therapyGas exchange abnormalitiesSleep apnea syndromeEye movement sleepSleep stage changesApnea syndromeOxygen therapyPhysiologic disturbancesMovement sleepSleep disordersSleep profilesPatientsObstructionSleepHypertensionArrhythmiasStage changesSyndrome