1989
Respiration and Abnormal Sleep in Patients with Congestive Heart Failure
Hanly B, Millar T, Steljes D, Boert R, Frais M, Kryger M. Respiration and Abnormal Sleep in Patients with Congestive Heart Failure. CHEST Journal 1989, 96: 480-488. PMID: 2766808, DOI: 10.1378/chest.96.3.480.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureStage 2 NREM sleepSlow-wave sleepSleep stage changesNREM sleepHyperpneic phaseHeart failureREM sleepAwake arterial oxygen saturationStable congestive heart failureSevere congestive heart failureStage 1Mean minimum SaO2Outcomes of patientsNumber of arousalsArterial oxygen saturationStage 1 sleepMinimum SaO2Severe hypoxemiaArterial oxygenationSignificant hypoxemiaClinical statusMean durationAbnormal sleep
1983
The role of protriptyline in obstructive sleep apnea.
Brownell L, Perez-Padilla R, West P, Kryger M. The role of protriptyline in obstructive sleep apnea. European Respiratory Journal 1983, 19: 621-4. PMID: 6360257.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTreatment of mildLong-term treatmentTricyclic agentsObese patientsObstructive apneaClinical statusCrossover trialImproved oxygenationInvasive treatmentTerm treatmentPatientsApneaArousal frequencySomnolenceProtriptylineTreatmentTrialsOxygenationREMTherapyMildMonths