2018
BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation
Britto CJ, Niu N, Khanal S, Huleihel L, Herazo-Maya J, Thompson A, Sauler M, Slade MD, Sharma L, Dela Cruz CS, Kaminski N, Cohn LE. BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2018, 316: l321-l333. PMID: 30461288, PMCID: PMC6397348, DOI: 10.1152/ajplung.00056.2018.Peer-Reviewed Original ResearchConceptsLung inflammationAcute inflammationC motif chemokine ligand 10Lung neutrophil recruitmentRegulation of CXCL10Acute lung inflammationBronchoalveolar lavage concentrationsChemokine ligand 10Innate immune responseIFN regulatory factorIntranasal LPSLavage concentrationsLung recruitmentNeutrophil recruitmentWT miceImmune effectsLung diseasePMN recruitmentInflammatory responseLPS treatmentLung tissueInflammatory signalsImmune responseImmunomodulatory propertiesInflammation
2016
D‐dopachrome tautomerase in adipose tissue inflammation and wound repair
Kim B, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R. D‐dopachrome tautomerase in adipose tissue inflammation and wound repair. Journal Of Cellular And Molecular Medicine 2016, 21: 35-45. PMID: 27605340, PMCID: PMC5192814, DOI: 10.1111/jcmm.12936.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsAntigens, Differentiation, B-LymphocyteCell MovementCell ProliferationDown-RegulationFibroblastsHistocompatibility Antigens Class IIHumansInflammationIntramolecular OxidoreductasesMacrophagesMaleMiceMice, Inbred C57BLObesityReceptors, CXCR4Receptors, Interleukin-8BUp-RegulationWound HealingConceptsAdipose tissue inflammationSubcutaneous adipose tissueD-DTAdipose tissueTissue inflammationWound repairEpididymal fat padsDopachrome tautomeraseReceptor CXCR2MIF antibodyInflammatory cellsReceptor CD74Healthy donorsReceptor expressionFat padMRNA expressionProtein levelsWound healingFibroblast survivalMIFInflammationHealingTissueCell migrationFibroblast wound healing
2015
Suppression of NLRX1 in chronic obstructive pulmonary disease
Kang MJ, Yoon CM, Kim BH, Lee CM, Zhou Y, Sauler M, Homer R, Dhamija A, Boffa D, West AP, Shadel GS, Ting JP, Tedrow JR, Kaminski N, Kim WJ, Lee CG, Oh YM, Elias JA. Suppression of NLRX1 in chronic obstructive pulmonary disease. Journal Of Clinical Investigation 2015, 125: 2458-2462. PMID: 25938787, PMCID: PMC4497738, DOI: 10.1172/jci71747.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseCigarette smokeAlveolar destructionPulmonary diseaseHuman chronic obstructive pulmonary diseaseExpression of NLRX1Innate immune pathwaysInnate immune responseQuality of lifeCOPD patientsPulmonary functionSubsequent inflammationImmune responseInflammasome activationMurine modelIndependent cohortImmune pathwaysInflammationDisease severityInflammasome responseImportant mediatorCell apoptosisNLRX1Tissue effects