Featured Publications
Development and validation of a prediction model for persistent functional impairment among older ICU survivors
Ferrante LE, Murphy TE, Leo‐Summers L, O'Leary JR, Vander Wyk B, Pisani MA, Gill TM. Development and validation of a prediction model for persistent functional impairment among older ICU survivors. Journal Of The American Geriatrics Society 2022, 71: 188-197. PMID: 36196998, PMCID: PMC9870848, DOI: 10.1111/jgs.18075.Peer-Reviewed Original ResearchConceptsPersistent functional impairmentICU hospitalizationFunctional impairmentValidation cohortICU admissionDevelopment cohortOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsOlder ICU survivorsMonths of dischargeHigh-risk survivorsCommunity-living participantsGood calibrationHospital lengthICU survivorsCritical illnessMedian agePrior hospitalizationFunctional recoveryNational HealthProbable dementiaHospitalizationHigh riskDepressive symptomsAssociation Between Socioeconomic Disadvantage and Decline in Function, Cognition, and Mental Health After Critical Illness Among Older Adults : A Cohort Study.
Jain S, Murphy TE, O'Leary JR, Leo-Summers L, Ferrante LE. Association Between Socioeconomic Disadvantage and Decline in Function, Cognition, and Mental Health After Critical Illness Among Older Adults : A Cohort Study. Annals Of Internal Medicine 2022, 175: 644-655. PMID: 35254879, PMCID: PMC9316386, DOI: 10.7326/m21-3086.Peer-Reviewed Original ResearchConceptsICU hospitalizationIntensive care unitMental healthCohort studyCritical illnessDual eligibilityOlder adultsProbable dementiaSocioeconomic disadvantageOlder personsGreater riskCommunity-dwelling older adultsLongitudinal cohort studySymptoms of depressionAging Trends StudyOutcome of functionMental health outcomesClinical characteristicsLow-income seniorsCare unitNational HealthRetrospective analysisHospitalizationOlder survivorsDaily livingAssociation of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness
Falvey JR, Cohen AB, O’Leary J, Leo-Summers L, Murphy TE, Ferrante LE. Association of Social Isolation With Disability Burden and 1-Year Mortality Among Older Adults With Critical Illness. JAMA Internal Medicine 2021, 181: 1433-1439. PMID: 34491282, PMCID: PMC8424527, DOI: 10.1001/jamainternmed.2021.5022.Peer-Reviewed Original ResearchConceptsCritical illnessICU hospitalizationSocial isolation scoresOlder adultsICU admissionCohort studyPrimary outcomeDisability burdenSocial isolationCommunity-dwelling older adultsGreater disability burdenIsolation scoresPost-ICU disabilityObservational cohort studyAging Trends StudyICU stayMortality cohortHospital dischargeSecondary outcomesHospital admissionMedian ageIllness severityAdverse outcomesNational HealthHospitalization dataNeighborhood Socioeconomic Disadvantage and Disability After Critical Illness*
Falvey JR, Murphy TE, Leo-Summers L, Gill TM, Ferrante LE. Neighborhood Socioeconomic Disadvantage and Disability After Critical Illness*. Critical Care Medicine 2021, 50: 733-741. PMID: 34636807, PMCID: PMC9001742, DOI: 10.1097/ccm.0000000000005364.Peer-Reviewed Original ResearchConceptsNeighborhood socioeconomic disadvantageDisability burdenHigher disability burdenCritical illnessSocioeconomic disadvantageOlder adultsCritical illness survivorsLongitudinal cohort studyArea Deprivation IndexDisadvantaged neighborhoodsNon-Hispanic whitesDifferent functional tasksICU admissionICU dischargeICU survivorsCohort studyDischarge destinationHospital dischargeFunctional recoveryNeighborhood disadvantageAdjusted modelCare servicesSecondary analysisSecondary objectiveIllnessSociety of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness.
Mikkelsen ME, Still M, Anderson BJ, Bienvenu OJ, Brodsky MB, Brummel N, Butcher B, Clay AS, Felt H, Ferrante LE, Haines KJ, Harhay MO, Hope AA, Hopkins RO, Hosey M, Hough CTL, Jackson JC, Johnson A, Khan B, Lone NI, MacTavish P, McPeake J, Montgomery-Yates A, Needham DM, Netzer G, Schorr C, Skidmore B, Stollings JL, Umberger R, Andrews A, Iwashyna TJ, Sevin CM. Society of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness. Critical Care Medicine 2020, 48: 1670-1679. PMID: 32947467, DOI: 10.1097/ccm.0000000000004586.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCritical illnessLong-term impairmentInternational Consensus ConferenceHospital dischargeSerial assessmentConsensus conferenceFunctional abilityCritical Care Medicine Consensus ConferenceSystematic reviewPost-intensive care syndromeCare coordination strategiesMontreal Cognitive Assessment (MoCA) testHigh-risk patientsHealth-related qualityMental health functionCognitive Assessment testOriginal systematic reviewAssessment of survivorsEvent Scale-RevisedICU admissionEuroQol-5DCochrane LibraryHospital AnxietyDepression ScaleLife measuresAGS Position Statement: Resource Allocation Strategies and Age‐Related Considerations in the COVID‐19 Era and Beyond
Farrell TW, Ferrante LE, Brown T, Francis L, Widera E, Rhodes R, Rosen T, Hwang U, Witt LJ, Thothala N, Liu SW, Vitale CA, Braun UK, Stephens C, Saliba D. AGS Position Statement: Resource Allocation Strategies and Age‐Related Considerations in the COVID‐19 Era and Beyond. Journal Of The American Geriatrics Society 2020, 68: 1136-1142. PMID: 32374440, PMCID: PMC7267615, DOI: 10.1111/jgs.16537.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAmerican Geriatrics SocietyOlder adultsAppropriate advance care planningShort-term outcomesRelevant clinical factorsCoronavirus disease 2019Advance care planningPotential short-term outcomeClinical factorsSevere illnessAdvanced ageDisease 2019Care planningMortality riskGeriatrics SocietySocial determinantsHealthcare professionalsHealth systemOlder peopleInterprofessional expertsEthics CommitteeCOVID-19 eraLife expectancyAgeCOVID-19The Combined Effects of Frailty and Cognitive Impairment on Post-ICU Disability among Older ICU Survivors
Ferrante LE, Murphy TE, Leo-Summers LS, Gahbauer EA, Pisani MA, Gill TM. The Combined Effects of Frailty and Cognitive Impairment on Post-ICU Disability among Older ICU Survivors. American Journal Of Respiratory And Critical Care Medicine 2019, 200: 107-110. PMID: 30883191, PMCID: PMC6603056, DOI: 10.1164/rccm.201806-1144le.Peer-Reviewed Original ResearchDual-Physician Households
Ferrante L, Mody L. Dual-Physician Households. JAMA 2019, 321: 2161-2162. PMID: 31074762, DOI: 10.1001/jama.2019.4413.Commentaries, Editorials and LettersThe Association of Frailty With Post-ICU Disability, Nursing Home Admission, and Mortality A Longitudinal Study
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. The Association of Frailty With Post-ICU Disability, Nursing Home Admission, and Mortality A Longitudinal Study. CHEST Journal 2018, 153: 1378-1386. PMID: 29559308, PMCID: PMC6026287, DOI: 10.1016/j.chest.2018.03.007.Peer-Reviewed Original ResearchConceptsNursing home admissionPost-ICU disabilityHome admissionCritical illnessFrailty statusGreater disabilityNew nursing home admissionsAssociation of frailtyLikelihood of deathOne-point increaseICU admissionICU survivorsICU outcomesMean agePrognostic informationPrefrailtyFried indexAdmissionFrailtyOlder personsParent cohortAnalytic sampleFunctional activityNonfrailtyDisabilityPre–Intensive Care Unit Cognitive Status, Subsequent Disability, and New Nursing Home Admission among Critically Ill Older Adults
Ferrante LE, Murphy TE, Gahbauer EA, Leo-Summers LS, Pisani MA, Gill TM. Pre–Intensive Care Unit Cognitive Status, Subsequent Disability, and New Nursing Home Admission among Critically Ill Older Adults. Annals Of The American Thoracic Society 2018, 15: 622-629. PMID: 29446993, PMCID: PMC5949607, DOI: 10.1513/annalsats.201709-702oc.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionNew nursing home admissionsNursing home admissionCare unit admissionHome admissionCritical illnessUnit admissionModerate impairmentCognitive statusCognitive impairmentOlder adultsMinimal impairmentMultivariable analysisIntensive care unit stayMini-Mental State ExaminationProspective cohort studyIll Older AdultsModerate cognitive impairmentUnit stayCohort studySecondary outcomesSubsequent disabilityPrimary outcomeMean agePrognostic informationIntegrating Geriatric Principles into Critical Care Medicine: The Time Is Now
Brummel NE, Ferrante LE. Integrating Geriatric Principles into Critical Care Medicine: The Time Is Now. Annals Of The American Thoracic Society 2018, 15: 518-522. PMID: 29298089, PMCID: PMC5949609, DOI: 10.1513/annalsats.201710-793ip.Commentaries, Editorials and LettersFactors Associated with Functional Recovery among Older Intensive Care Unit Survivors
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Factors Associated with Functional Recovery among Older Intensive Care Unit Survivors. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 299-307. PMID: 26840348, PMCID: PMC4970594, DOI: 10.1164/rccm.201506-1256oc.Peer-Reviewed Original ResearchConceptsHigher body mass indexOlder ICU survivorsIntensive care unitBody mass indexFunctional recoveryICU survivorsICU admissionMass indexOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsPoor functional recoveryCritical illnessIndependent predictorsCare unitMultivariable analysisFunctional outcomePremorbid functionPotential predictorsVision impairmentAdmissionSurvivorsAnalytic sampleFunctional activityMonthsFunctional Trajectories Among Older Persons Before and After Critical Illness
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.Peer-Reviewed Original ResearchConceptsIntensive care unitLong-term mortalityCritical illnessICU admissionModerate disabilityOlder personsMinimal disabilitySevere disabilityFunctional trajectoriesFunctional declineEarly deathProspective cohort studyDay of admissionPersons 70 yearsGoals of careRisk of deathShort-term mortalityGreater New HavenSignificant functional declineICU lengthCohort studyHospital dischargePremorbid disabilityCare unitMechanical ventilationFrailty is crucial in FORECASTing outcomes in critical care
Ferrante L, Szczeklik W. Frailty is crucial in FORECASTing outcomes in critical care. Intensive Care Medicine 2024, 50: 1119-1122. PMID: 38953928, PMCID: PMC11556853, DOI: 10.1007/s00134-024-07518-0.Commentaries, Editorials and LettersIn-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeTackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report.
Palakshappa J, Batt J, Bodine S, Connolly B, Doles J, Falvey J, Ferrante L, Files D, Harhay M, Harrell K, Hippensteel J, Iwashyna T, Jackson J, Lane-Fall M, Monje M, Moss M, Needham D, Semler M, Lahiri S, Larsson L, Sevin C, Sharshar T, Singer B, Stevens T, Taylor S, Gomez C, Zhou G, Girard T, Hough C. Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report. American Journal Of Respiratory And Critical Care Medicine 2024, 209: 1304-1313. PMID: 38477657, PMCID: PMC11146564, DOI: 10.1164/rccm.202311-2130ws.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNational HeartAcute respiratory distress syndrome survivorsEvidence-based interventionsQuality of lifeAssociated with long-term impairmentNational Institutes of HealthInstitutes of HealthAcute respiratory distress syndromeBlood InstituteARDS survivorsMuscle functionAcute illnessMuscle dysfunctionLong-term impairmentNational InstituteHealthSurvivorsRespiratory distress syndromeNationalWorkshopMuscleImpairmentDistress syndromeNHLBIInterventionEffect of a Three-Component Geriatrics Bundle on Incident Delirium among Critically Ill Older Adults: A Pilot Clinical Trial.
Ferrante L, Han L, Andrews B, Cohen A, Davis J, Gritsenko D, Lee S, Pisani M, Reed N, Rouse G, Truebig J. Effect of a Three-Component Geriatrics Bundle on Incident Delirium among Critically Ill Older Adults: A Pilot Clinical Trial. Annals Of The American Thoracic Society 2024, 21: 1333-1337. PMID: 38785442, PMCID: PMC11376353, DOI: 10.1513/annalsats.202311-963rl.Peer-Reviewed Original ResearchSocial Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization
Jain S, Murphy T, Falvey J, Leo-Summers L, O’Leary J, Zang E, Gill T, Krumholz H, Ferrante L. Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization. JAMA Network Open 2024, 7: e2410713. PMID: 38728030, PMCID: PMC11087837, DOI: 10.1001/jamanetworkopen.2024.10713.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthOccupational therapyPhysical therapyOlder adultsRural residentsIntensive care unit hospitalizationRehabilitation deliveryIntensive care unitSocial determinantsSocioeconomic disadvantageNational Health and Aging Trends StudyDelivery of physical therapyIllness hospitalizationFactors associated with lower oddsDelivery of rehabilitationIn-hospital rehabilitationMitigate functional declineMedicaid eligibilityBurden of disabilityHigh school educationDual MedicareTrends StudyMedicare claimsLength of stayAll the Lonely People: Social Isolation and Loneliness in Chronic Obstructive Pulmonary Disease
Ferrante L, Cohen A. All the Lonely People: Social Isolation and Loneliness in Chronic Obstructive Pulmonary Disease. Annals Of The American Thoracic Society 2023, 20: 1703-1704. PMID: 38038602, PMCID: PMC10704229, DOI: 10.1513/annalsats.202309-833ed.Commentaries, Editorials and LettersFeasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study
Stevenson J, Murphy T, Tessier-Sherman B, Pisani M, Gill T, Ferrante L. Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors A Pilot Study. CHEST Critical Care 2024, 2: 100093. DOI: 10.1016/j.chstcc.2024.100093.Peer-Reviewed Original ResearchRisk prediction toolsICU survivorsIn-hospital administrationOlder adultsFunctional impairmentPilot studyIn-hospital mobilityOlder ICU survivorsDevelopment of risk prediction modelsHospital-related factorsIn-hospital factorsPresence of deliriumRisk prediction modelModel discriminationPersistent functional impairmentStatistical significanceHospital settingStudy designFeasibility thresholdDaily activitiesIncreased riskInternational Consensus ConferenceConsensus conferenceSurvivorsCritical illness