2023
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly intervention
2015
The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods
Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.Peer-Reviewed Original ResearchConceptsCardiovascular outcomesVascular eventsSleep architecturePrognostic modelRetrospective observational cohort studyMain primary outcomeMiddle-aged veteransTransient ischemic attackAcute coronary syndromeObservational cohort studyResultsThe study populationCongestive heart failureSleep-disordered breathingVA Patient Treatment FileVital Status filesPatient Treatment FileComputerized patient record systemVeterans Affairs centersPost-traumatic stress disorderIschemic attackCoronary syndromeCohort studySecondary outcomesComposite endpointGlycemic control
2005
Obstructive Sleep Apnea as a Risk Factor for Stroke and Death
Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death. New England Journal Of Medicine 2005, 353: 2034-2041. PMID: 16282178, DOI: 10.1056/nejmoa043104.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeApnea-hypopnea indexMean apnea-hypopnea indexRisk of strokeApnea syndromeRisk factorsSleep apneaComposite end pointObservational cohort studyObstructive sleep apneaProportional hazards analysisComparison groupAlcohol consumption statusBody mass indexImportant risk factorCohort studyComposite outcomeConsecutive patientsDiabetes mellitusSmoking statusAtrial fibrillationUnadjusted analysesSyndromePatients