2015
Chitinase 3–like-1 Regulates Both Visceral Fat Accumulation and Asthma-like Th2 Inflammation
Ahangari F, Sood A, Ma B, Takyar S, Schuyler M, Qualls C, Dela Cruz CS, Chupp GL, Lee CG, Elias JA. Chitinase 3–like-1 Regulates Both Visceral Fat Accumulation and Asthma-like Th2 Inflammation. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 746-757. PMID: 25629580, PMCID: PMC4407482, DOI: 10.1164/rccm.201405-0796oc.Peer-Reviewed Original ResearchConceptsHigh-fat dietTh2 inflammationTh2 responsesFat accumulationChitinase 3Genesis of obesityRole of CHI3L1Lower lung functionLean control subjectsVisceral fat accumulationPathogenesis of asthmaWhite adipose tissue accumulationAdipose tissue accumulationCase-control studySerum CHI3L1Truncal adiposityWAT accumulationPersistent asthmaTruncal obesityLung functionObese subjectsVisceral fatAsthma incidenceControl subjectsRisk factors
2012
Chitinase-like Proteins in Lung Injury, Repair, and Metastasis
Lee CG, Dela Cruz CS, Ma B, Ahangari F, Zhou Y, Halaban R, Sznol M, Elias JA. Chitinase-like Proteins in Lung Injury, Repair, and Metastasis. Annals Of The American Thoracic Society 2012, 9: 57-61. PMID: 22550243, PMCID: PMC3359113, DOI: 10.1513/pats.201112-056ms.Peer-Reviewed Original Research
2011
Studies of Vascular Endothelial Growth Factor in Asthma and Chronic Obstructive Pulmonary Disease
Lee CG, Ma B, Takyar S, Ahangari F, DelaCruz C, He CH, Elias JA. Studies of Vascular Endothelial Growth Factor in Asthma and Chronic Obstructive Pulmonary Disease. Annals Of The American Thoracic Society 2011, 8: 512-515. PMID: 22052929, PMCID: PMC3359071, DOI: 10.1513/pats.201102-018mw.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorRIG-like helicaseTh2 inflammationEndothelial growth factorImmune pathwaysVirus-induced COPD exacerbationsChronic obstructive pulmonary diseaseViral pathogen-associated molecular patternsRole of VEGFGrowth factorDendritic cell activationObstructive pulmonary diseaseAbrogation of VEGFInnate immune pathwaysUseful therapeutic strategyVEGF receptor blockadePathogen-associated molecular patternsTissue responseCOPD exacerbationsMucus metaplasiaEosinophilic inflammationReceptor blockadePulmonary diseaseSubepithelial fibrosisCytokine elaborationRole of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury
Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury. Annual Review Of Physiology 2011, 73: 479-501. PMID: 21054166, PMCID: PMC3864643, DOI: 10.1146/annurev-physiol-012110-142250.Peer-Reviewed Original ResearchConceptsBRP-39/YKLAdaptive Th2 immunityTissue remodelingChitinase-like proteinsAlternative macrophage activationTh2 inflammationInnate inflammationLung injuryTh2 immunityAcidic mammalian chitinaseAncient gene familyIL-13YKL-40Tissue injuryNumber of chitinasesEffector functionsMacrophage activationFamily of chitinasesInflammationDisease severityInjuryRole of chitinMammalian chitinaseGene familyEndogenous chitin