2024
Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease
Swaminathan A, McFatrich M, Mkumba L, Wright L, Redlich C, Snyder L, Reeve B, Patel D, Gulati M. Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease. Respiratory Research 2024, 25: 372. PMID: 39407223, PMCID: PMC11481565, DOI: 10.1186/s12931-024-03000-z.Peer-Reviewed Original ResearchConceptsCognitive interviewsContent validityExposure questionnaireMultidisciplinary teamSemi-structured interview guideEvidence of content validityFibrosing ILDsInterstitial lung diseaseRelevant exposuresFibrotic interstitial lung diseaseClinically relevant exposuresTrained interviewersInterview guideAssessment QuestionnaireQuestionnaireInterviewsLung diseaseAdultsTeamClinicPatientsSource of misunderstandingOccupational inhalation exposureValidityDisease
2022
Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses
Wisnewski AV, Liu J, Lucas C, Klein J, Iwasaki A, Cantley L, Fazen L, Luna J, Slade M, Redlich CA. Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses. PLOS ONE 2022, 17: e0262657. PMID: 35041700, PMCID: PMC8765639, DOI: 10.1371/journal.pone.0262657.Peer-Reviewed Original ResearchConceptsPlaque reduction neutralization testCOVID-19 patientsVaccine responsesRecovered COVID-19 patientsSARS-CoV-2 immunityBooster vaccine dosesMRNA vaccine responsePost-vaccine seraCompetitive ELISAEnzyme 2 (ACE2) receptorReduction neutralization testType of vaccineSARS-CoV-2 spike protein receptorSpike protein receptorVaccine seraVaccine recipientsPost vaccinationVaccinated individualsVaccine dosesViral culturePrior historyViral neutralizationNeutralization testBooster shotsPost vaccine
2021
Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel
Zell J, Wisnewski AV, Liu J, Klein J, Lucas C, Slade M, Iwasaki A, Redlich CA. Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel. PLOS ONE 2021, 16: e0251114. PMID: 34460832, PMCID: PMC8405017, DOI: 10.1371/journal.pone.0251114.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Live SARS-CoV-2Moderate SARS-CoV-2SARS-CoV-2 seroprevalenceWork-related risk factorsTransportation-related occupationsSerum IgG levelsAntigen-specific IgGIgG seropositivity rateBiomarkers of infectionSARS-CoV-2 spikeCOVID-19 exposureUS National Guard soldiersMilitary personnelIgG levelsSeropositivity rateHumoral responseSerum IgGViral exposureBlack raceRisk factorsOdds ratioStudy populationNational Guard soldiersDemographic dataHuman IgG and IgA responses to COVID-19 mRNA vaccines
Wisnewski AV, Luna J, Redlich CA. Human IgG and IgA responses to COVID-19 mRNA vaccines. PLOS ONE 2021, 16: e0249499. PMID: 34133415, PMCID: PMC8208542, DOI: 10.1371/journal.pone.0249499.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccinesAntigen-specific IgGMRNA vaccinesIgG levelsCOVID-19 mRNA vaccinationAntigen-specific IgG levelsInitial vaccine doseAntigen-specific IgASARS-CoV-2More rapid declineSecond vaccineVaccine doseMRNA vaccinationIgA responsesSerum levelsVaccine dosesSpecific IgGNatural immunityViral neutralizationIgAVaccinePeak levelsIgGVaccinationHuman IgGSARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate Among the Non-Congregate Population in Connecticut
Mahajan S, Caraballo C, Li SX, Dong Y, Chen L, Huston SK, Srinivasan R, Redlich CA, Ko AI, Faust JS, Forman HP, Krumholz HM. SARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate Among the Non-Congregate Population in Connecticut. The American Journal Of Medicine 2021, 134: 812-816.e2. PMID: 33617808, PMCID: PMC7895685, DOI: 10.1016/j.amjmed.2021.01.020.Peer-Reviewed Original ResearchConceptsInfection hospitalization rateInfection fatality rateHospitalization ratesFatality rateSeroprevalence estimatesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodiesSARS-CoV-2 antibodiesConnecticut Hospital AssociationNon-Hispanic black peopleProportion of deathsCoronavirus disease 2019Total infected individualsTotal hospitalizationsAdverse outcomesNon-congregate settingsHigh burdenDisease 2019Prevalence studyMost subgroupsInfected individualsHospitalizationOlder peopleHospital AssociationConnecticut DepartmentDeath
2020
Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study
Mahajan S, Srinivasan R, Redlich CA, Huston SK, Anastasio KM, Cashman L, Massey DS, Dugan A, Witters D, Marlar J, Li SX, Lin Z, Hodge D, Chattopadhyay M, Adams MD, Lee C, Rao LV, Stewart C, Kuppusamy K, Ko AI, Krumholz HM. Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study. The American Journal Of Medicine 2020, 134: 526-534.e11. PMID: 33130124, PMCID: PMC7598362, DOI: 10.1016/j.amjmed.2020.09.024.Peer-Reviewed Original ResearchConceptsSARS-CoV-2-specific IgG antibodiesWeighted seroprevalenceIgG antibodiesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodiesSARS-CoV-2-specific antibodiesConnecticut residentsSelf-reported adherenceImmunoglobulin G antibodiesSARS-CoV-2Symptomatic illnessSerology testingSeroprevalence studyG antibodiesPrevalence studyGeneral populationPercentage of peopleSeroprevalenceLack antibodiesMajority of respondentsAntibodiesHispanic subpopulationsConvenience sampleHispanic populationCOVID-19Risk mitigation behaviorsAnalysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology
Wisnewski AV, Liu J, Redlich CA. Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology. American Journal Of Respiratory Cell And Molecular Biology 2020, 0: 25-35. PMID: 32101465, PMCID: PMC7328250, DOI: 10.1165/rcmb.2019-0400oc.Peer-Reviewed Original ResearchConceptsRespiratory tract exposureAirway eosinophiliaMonocytes/macrophagesMouse modelGene expressionGene transcriptsBiological pathwaysAsthma pathologyUpregulated gene transcriptsIgE-independent mechanismsLung gene expressionLung tissue gene expressionCause of asthmaBALB/cTransgenic B cellsTissue gene expressionExpression changesDiisocyanate asthmaSensitized workersAsthma pathogenesisAirway fluidDeficient miceMRNA microarrayEosinophiliaB cells
2019
Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report
Garshick E, Abraham JH, Baird CP, Ciminera P, Downey GP, Falvo MJ, Hart JE, Jackson DA, Jerrett M, Kuschner W, Helmer DA, Jones KD, Krefft SD, Mallon T, Miller RF, Morris MJ, Proctor SP, Redlich CA, Rose CS, Rull RP, Saers J, Schneiderman AI, Smith NL, Yiallouros P, Blanc PD. Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2019, 16: e1-e16. PMID: 31368802, PMCID: PMC6774741, DOI: 10.1513/annalsats.201904-344ws.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsConstrictive bronchiolitisAirway diseaseRespiratory healthOfficial American Thoracic Society Workshop ReportRespiratory tract findingsRespiratory tract abnormalitiesAdverse health conditionsParticulate matter effectsU.S. military personnelLung biopsyLung functionPulmonary functionCase seriesPathologic findingsTract abnormalitiesInhalational exposurePhysiologic changesClinical characterizationAmerican Thoracic Society International ConferenceEpidemiologic studiesBronchiolitisLongitudinal assessmentDeployment exposuresHealth conditionsMore frequent encountersThe Occupational Burden of Nonmalignant Respiratory Diseases. An Official American Thoracic Society and European Respiratory Society Statement
Blanc PD, Annesi-Maesano I, Balmes JR, Cummings KJ, Fishwick D, Miedinger D, Murgia N, Naidoo RN, Reynolds CJ, Sigsgaard T, Torén K, Vinnikov D, Redlich CA. The Occupational Burden of Nonmalignant Respiratory Diseases. An Official American Thoracic Society and European Respiratory Society Statement. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1312-1334. PMID: 31149852, PMCID: PMC6543721, DOI: 10.1164/rccm.201904-0717st.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNonmalignant respiratory diseasesChronic obstructive pulmonary diseaseObstructive pulmonary diseasePopulation attributable fractionChronic respiratory diseasesRespiratory diseaseWorkplace exposuresPulmonary diseaseHypersensitivity pneumonitisAttributable fractionOccupational burdenOfficial American Thoracic SocietyEuropean Respiratory Society statementCommunity-acquired pneumoniaGranulomatous lung diseaseIdiopathic pulmonary fibrosisPopulation-based studyIncidence rate ratiosPulmonary alveolar proteinosisBurden of diseaseAmerican Thoracic SocietyWorking-age adultsPublic health awarenessAirway diseaseChronic bronchitis
2017
Injury, illness, and disability risk in American seafarers
Lefkowitz RY, Slade MD, Redlich CA. Injury, illness, and disability risk in American seafarers. American Journal Of Industrial Medicine 2017, 61: 120-129. PMID: 29250811, DOI: 10.1002/ajim.22802.Peer-Reviewed Original ResearchMeSH KeywordsAdultDatabases, FactualFemaleGastrointestinal DiseasesHumansLogistic ModelsMaleMiddle AgedNaval MedicineOccupational DiseasesOccupational InjuriesOdds RatioRespiratory Tract DiseasesRetrospective StudiesRiskShipsSkin DiseasesStomatognathic DiseasesTelemedicineTransportationUnited StatesConceptsDisability riskHigher disability riskOverall injury rateLogistic regression modelingResultant disabilityRisk factorsHigh riskIllness incidenceInjury ratesPreventive interventionsMedical careIllness ratesInjuryTelemedicine databaseIllnessRegression modelingEssential workforceDescriptive statistical methodsRiskAdditional researchDisabilityIncidenceCareMedical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States
Cassidy LD, Doney B, Wang ML, Kurth L, Conner PR, Collins JJ, Carson M, Molenaar D, Redlich CA, Storey E. Medical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States. Journal Of Occupational And Environmental Medicine 2017, 59: s13-s21. PMID: 29200134, PMCID: PMC5728423, DOI: 10.1097/jom.0000000000001197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAsthma, OccupationalChemical IndustryEnvironmental MonitoringFemaleForced Expiratory VolumeHumansMaleMiddle AgedOccupational ExposurePopulation SurveillanceProgram EvaluationReferral and ConsultationSpirometrySurveys and QuestionnairesSymptom AssessmentToluene 2,4-DiisocyanateUnited StatesYoung AdultConceptsLung function criteriaOccupational health programWeb-based data collection systemTDI workersOccupational asthmaPossible asthmaStudy protocolHealth outcomesMultidisciplinary teamHealth programsMedical monitoringAsthmaFurther evaluationEligible workersFurther assessmentResearch protocolPotential casesSubsequent evaluationProduction workersSymptomsToluene diisocyanateWorkersEvaluationIncidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry
Collins JJ, Anteau S, Conner PR, Cassidy LD, Doney B, Wang ML, Kurth L, Carson M, Molenaar D, Redlich CA, Storey E. Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry. Journal Of Occupational And Environmental Medicine 2017, 59: s22-s27. PMID: 29200135, PMCID: PMC5763544, DOI: 10.1097/jom.0000000000000890.Peer-Reviewed Original ResearchImproving the asthma disparity gap with legal advocacy? A qualitative study of patient-identified challenges to improve social and environmental factors that contribute to poorly controlled asthma
Harris DA, Mainardi A, Iyamu O, Rosenthal MS, Bruce RD, Pisani MA, Redlich CA. Improving the asthma disparity gap with legal advocacy? A qualitative study of patient-identified challenges to improve social and environmental factors that contribute to poorly controlled asthma. Journal Of Asthma 2017, 55: 924-932. PMID: 28872933, DOI: 10.1080/02770903.2017.1373393.Peer-Reviewed Original ResearchConceptsPoor symptom controlSymptom controlAsthma Control Test scoresCommon barriersCommunity health centersWork-related symptomsEnvironmental risk factorsPercent of participantsCommunity-engaged approachAsthmatic adultsAsthma controlRisk factorsAsthma triggersHealth centersImproved outcomesMedical careDisparity gapStudy participantsPerson interviewsLack of awarenessAsthmaPatientsConstant comparative methodEnvironmental factorsAdultsThe Limits of Pattern Recognition: Nodular Lung Disease in a Syrian Refugee
Lefkowitz RY, Mitma AA, Altassan K, Redlich CA. The Limits of Pattern Recognition: Nodular Lung Disease in a Syrian Refugee. Annals Of The American Thoracic Society 2017, 14: 1591-1594. PMID: 28961033, DOI: 10.1513/annalsats.201702-163cc.Peer-Reviewed Case Reports and Technical NotesReaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy
Wisnewski AV, Kanyo J, Asher J, Goodrich JA, Barnett G, Patrylak L, Liu J, Redlich CA, Nassar AF. Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy. Xenobiotica 2017, 48: 488-497. PMID: 28489470, PMCID: PMC5863241, DOI: 10.1080/00498254.2017.1329569.Peer-Reviewed Original ResearchConceptsCollision-induced dissociation (CID) fragmentation patternsReaction productsLower airwaysChemical reactivityLow molecular weight fractionWeight fractionHigh molecular weight fractionAliphatic diisocyanateMolecular weight fractionFragmentation patternsHexamethylenediisocyanateLC-MSHDI vaporAirways of rabbitsBronchoalveolar lavage fluidRabbit bronchoalveolar lavage fluidMoleculesDiisocyanate vaporsMs. 4Albumin. 5Occupational asthmaReactivityBAL fluidAsthma pathogenesisLavage fluid
2016
Patterns of Energy Drink Use and Associated Symptoms Among a Population of Connecticut Factory Workers
Pensa MA, Galusha DH, Stowe MH, Lefkowitz RY, Redlich CA. Patterns of Energy Drink Use and Associated Symptoms Among a Population of Connecticut Factory Workers. Journal Of Occupational And Environmental Medicine 2016, 58: e188-e190. PMID: 27158968, DOI: 10.1097/jom.0000000000000728.Peer-Reviewed Original Research
2015
Elevated Blood Lead Levels Related to the Use of Firearms
Cook JM, Sakr CJ, Redlich CA, DeLoreto AL. Elevated Blood Lead Levels Related to the Use of Firearms. Journal Of Occupational And Environmental Medicine 2015, 57: e136-e138. PMID: 26461876, DOI: 10.1097/jom.0000000000000553.Peer-Reviewed Case Reports and Technical NotesRisk factors for merchant seafarer repatriation due to injury or illness at sea
Lefkowitz RY, Slade MD, Redlich CA. Risk factors for merchant seafarer repatriation due to injury or illness at sea. International Maritime Health 2015, 66: 61-66. PMID: 26119673, DOI: 10.5603/imh.2015.0016.Peer-Reviewed Original ResearchConceptsRisk factorsLogistic regressionModifiable risk factorsSignificant risk factorsFrequent causeGastrointestinal illnessSerious outcomesIllness casesBack injuriesInjuryIllnessSeafarer injuryTelemedicine databaseMajor causeStudy periodDescriptive statisticsYear periodFuture studiesCauseFactorsRegressionCohortStudy“Injury, illness, and work restriction in merchant seafarers”
Lefkowitz RY, Slade MD, Redlich CA. “Injury, illness, and work restriction in merchant seafarers”. American Journal Of Industrial Medicine 2015, 58: 688-696. PMID: 25939921, DOI: 10.1002/ajim.22459.Peer-Reviewed Original Research
2014
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up
Gui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAirway ObstructionAsthma, OccupationalFemaleFollow-Up StudiesForced Expiratory VolumeHumansImmunoglobulin EImmunoglobulin GLost to Follow-UpMaleMiddle AgedOccupational ExposurePolyurethanesPrevalenceProspective StudiesTime FactorsToluene 2,4-DiisocyanateVital CapacityYoung AdultConceptsAsthma symptomsIsocyanate asthmaInception cohort studyHealth effectsCurrent asthma symptomsTDI levelsFirst yearFurther longitudinal evaluationAirflow obstructionCohort studyInception cohortOccupational asthmaTDI exposureRespiratory healthSkin exposureLongitudinal evaluationAsthmaOne-yearPersonal samplingSymptomsRiskExposureFindingsFEV1Spirometry