2021
Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory
Wisnewski AV, Redlich CA. Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory. American Journal Of Industrial Medicine 2021, 64: 1055-1056. PMID: 34647343, DOI: 10.1002/ajim.23299.Commentaries, Editorials and Letters
2017
Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry
Collins JJ, Anteau S, Conner PR, Cassidy LD, Doney B, Wang ML, Kurth L, Carson M, Molenaar D, Redlich CA, Storey E. Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry. Journal Of Occupational And Environmental Medicine 2017, 59: s22-s27. PMID: 29200135, PMCID: PMC5763544, DOI: 10.1097/jom.0000000000000890.Peer-Reviewed Original Research
2014
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up
Gui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAirway ObstructionAsthma, OccupationalFemaleFollow-Up StudiesForced Expiratory VolumeHumansImmunoglobulin EImmunoglobulin GLost to Follow-UpMaleMiddle AgedOccupational ExposurePolyurethanesPrevalenceProspective StudiesTime FactorsToluene 2,4-DiisocyanateVital CapacityYoung AdultConceptsAsthma symptomsIsocyanate asthmaInception cohort studyHealth effectsCurrent asthma symptomsTDI levelsFirst yearFurther longitudinal evaluationAirflow obstructionCohort studyInception cohortOccupational asthmaTDI exposureRespiratory healthSkin exposureLongitudinal evaluationAsthmaOne-yearPersonal samplingSymptomsRiskExposureFindingsFEV1Spirometry
2009
Letters to the Editor
Redlich CA, Bello D, Woskie SR, Streicher RP, Booth K, Cummings B, Karoly W, Spence M, Mullins S, Robert W, Lichtenberg F, Banta J. Letters to the Editor. Journal Of Occupational And Environmental Hygiene 2009, 6: d82-d85. PMID: 19757291, DOI: 10.1080/15459620903256427.Commentaries, Editorials and LettersAir Pollutants, OccupationalAir Pollution, IndoorEnvironmental MonitoringHumansIsocyanatesOccupational Exposure
2008
Comparison of Task-Based Exposure Metrics for an Epidemiologic Study of Isocyanate Inhalation Exposures Among Autobody Shop Workers
Woskie SR, Bello D, Gore RJ, Stowe MH, Eisen EA, Liu Y, Sparer JA, Redlich CA, Cullen MR. Comparison of Task-Based Exposure Metrics for an Epidemiologic Study of Isocyanate Inhalation Exposures Among Autobody Shop Workers. Journal Of Occupational And Environmental Hygiene 2008, 5: 588-598. PMID: 18615291, DOI: 10.1080/15459620802275429.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollutants, OccupationalAlgorithmsAutomobilesEnvironmental MonitoringHumansInhalation ExposureIsocyanatesOccupational ExposureRisk AssessmentConceptsQuantitative exposure metricsOccupational exposure limitsEpidemiologic studiesExposure metricsRespirator useCross-week changesExposure-response analysisTime-weighted average exposureShop workersExposure assessmentPersonal daily exposureMagnitude of associationOccupational epidemiologic studiesWorkplace protection factorsQuantitative exposure assessmentTask-based exposure assessmentRespiratory functionInhalation exposureDaily exposureAverage exposureRisk estimatesExposure misclassificationQuantitative exposureSpearman correlationComparison of tasksLung/skin connections in occupational lung disease
Redlich CA, Herrick CA. Lung/skin connections in occupational lung disease. Current Opinion In Allergy And Clinical Immunology 2008, 8: 115-119. PMID: 18317018, DOI: 10.1097/aci.0b013e3282f85a31.Peer-Reviewed Original ResearchConceptsOccupational lung diseaseLung diseaseChronic beryllium diseaseSkin exposureIsocyanate asthmaBeryllium diseaseSite of sensitizationSubsequent inhalation challengeEnvironmental lung diseaseLimited clinical studiesImpair skin barrier functionSkin barrier functionAsthmatic responseInhalation challengeRespiratory tractHuman skin exposureClinical studiesInhalation exposureRecent studiesAnimal studiesAirborne exposureDiseaseBarrier functionPersonal protective clothingProtein allergensSkin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment
Bello D, Redlich CA, Stowe MH, Sparer J, Woskie SR, Streicher RP, Hosgood HD, Liu Y. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: II. A Quantitative Assessment. Annals Of Work Exposures And Health 2008, 52: 117-124. PMID: 18209009, DOI: 10.1093/annhyg/mem066.Peer-Reviewed Original ResearchConceptsSkin exposureUnprotected skinAuto body shop workersAuto Body RepairRespiratory exposureSkin areasExposure dataShop workersSkin samplingSkinExposureWipe samplesUnpaired samplesHigh concentrationsPPEGm loadYale studyHigh levelsBody repairAsthmaMajor contributorLevelsQuantitative assessmentForearmSensitization
2007
Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: A Qualitative Assessment
LIU Y, BELLO D, SPARER JA, STOWE MH, GORE RJ, WOSKIE SR, CULLEN MR, REDLICH CA. Skin Exposure to Aliphatic Polyisocyanates in the Auto Body Repair and Refinishing Industry: A Qualitative Assessment. Annals Of Work Exposures And Health 2007, 51: 429-439. PMID: 17602207, DOI: 10.1093/annhyg/mem021.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollutants, OccupationalAutomobilesChromatography, High Pressure LiquidColorimetryHazardous SubstancesHumansIsocyanatesOccupational ExposurePaintPolyurethanesSkin AbsorptionConceptsAuto body shop workersSkin exposureHigh-performance liquid chromatographyShop workersHigher positive rateAuto Body RepairPositive surface samplesPositive sample rateEpidemiologic studiesUnprotected skinRespiratory exposurePercent of samplesSensitive high-performance liquid chromatographyLatex glovesScale 0Exposure dataExposure determinantsSkin samplesQuantitative high-performance liquid chromatographyNational InstituteOccupational SafetyAuto body shopsExposureMajor determinantPositive rate
2006
Skin Exposure to Isocyanates: Reasons for Concern
Bello D, Herrick CA, Smith TJ, Woskie SR, Streicher RP, Cullen MR, Liu Y, Redlich CA. Skin Exposure to Isocyanates: Reasons for Concern. Environmental Health Perspectives 2006, 115: 328-335. PMID: 17431479, PMCID: PMC1849909, DOI: 10.1289/ehp.9557.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAir Pollutants, OccupationalAnimalsAsthmaHumansIsocyanatesOccupational DiseasesOccupational ExposureSkinSkin AbsorptionConceptsSkin exposureIsocyanate asthmaSuch exposureAsthma-like responsesSubsequent inhalation challengeOccupational SafetyPersonal protective equipmentInhalation challengeOccupational asthmaSystemic sensitizationAsthmaInhalation exposureHealth AdministrationComputerized searchRespiratory exposureRelevant articlesProtective equipmentHuman literatureSkin absorptionSensitizationGoogle databasesNational InstituteLines of evidencePotential roleSufficient evidenceRespiratory Protection from Isocyanate Exposure in the Autobody Repair and Refinishing Industry
Liu Y, Stowe MH, Bello D, Woskie SR, Sparer J, Gore R, Youngs F, Cullen MR, Redlich CA. Respiratory Protection from Isocyanate Exposure in the Autobody Repair and Refinishing Industry. Journal Of Occupational And Environmental Hygiene 2006, 3: 234-249. PMID: 16574607, DOI: 10.1080/15459620600628704.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAutomobilesConnecticutEnvironmental MonitoringHumansInhalation ExposureIsocyanatesOccupational ExposurePaintRespiratory Protective DevicesConceptsWorkplace protection factorsIsocyanate exposureHalf-facepiece respiratorsRespiratory protectionFit factorsRespiratory protection programTotal isocyanate groupRespirator Fit FactorsOrganic vapor cartridgesShort-term exposure limitNegative pressureGM concentrationsPriming activitySignificant differencesExposure limitsUse trainingExposureRespiratorsProtection factorSecond testWorkersPortaCount
2005
Glutathione protects human airway proteins and epithelial cells from isocyanates
Wisnewski AV, Liu Q, Liu J, Redlich CA. Glutathione protects human airway proteins and epithelial cells from isocyanates. Clinical & Experimental Allergy 2005, 35: 352-357. PMID: 15784115, DOI: 10.1111/j.1365-2222.2005.02185.x.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollutants, OccupationalAsthmaCell LineCyanatesEpithelial CellsGlutathioneHumansHypersensitivityIsocyanatesOccupational DiseasesRespiratory MucosaConceptsDose-dependent mannerAirway fluidGSH levelsHuman airway epithelial cellsVapor exposure systemEpithelial cellsHuman airway epithelial cell lineAirway epithelial cell lineEpithelial lining fluidAirway epithelial cellsEpithelial cell exposureEpithelial cell toxicityAllergic sensitizationEpithelial cell lineHDI exposureAirway proteinsLining fluidAirway cellsIsocyanate exposureVivo exposureOccupational limitsNCI-H292Physiologic levelsEpithelial fluidToxicity studies
2004
Polyisocyanates in occupational environments: A critical review of exposure limits and metrics
Bello D, Woskie SR, Streicher RP, Liu Y, Stowe MH, Eisen EA, Ellenbecker MJ, Sparer J, Youngs F, Cullen MR, Redlich CA. Polyisocyanates in occupational environments: A critical review of exposure limits and metrics. American Journal Of Industrial Medicine 2004, 46: 480-491. PMID: 15490474, DOI: 10.1002/ajim.20076.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsUrinary Hexane Diamine to Assess Respiratory Exposure to Hexamethylene Diisocyanate Aerosol: A Human Inhalation Study
Liu Y, Berode M, Stowe MH, Holm CT, Walsh FX, Slade MD, Boeniger MF, Redlich CA. Urinary Hexane Diamine to Assess Respiratory Exposure to Hexamethylene Diisocyanate Aerosol: A Human Inhalation Study. International Journal Of Occupational And Environmental Health 2004, 10: 262-271. PMID: 15473079, DOI: 10.1179/oeh.2004.10.3.262.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAerosolsAgedAir Pollutants, OccupationalBiomarkersCyanatesDiaminesFemaleHumansInhalation ExposureIsocyanatesMaleMiddle AgedOccupational ExposureConceptsRespiratory exposureAuto body shop workersAcute respiratory exposureHours post exposureHuman respiratory exposureBiomarkers of exposureHuman inhalation studiesHDI exposureInhalation studiesBaseline valuesConsiderable individual variabilityPost exposureUrine samplesShop workersExposureBiomarkersIndividual variabilityHoursBaselineDeterminants of Isocyanate Exposures in Auto Body Repair and Refinishing Shops
Woskie S, Sparer J, Gore R, Stowe M, Bello D, Liu Y, Youngs F, Redlich C, Eisen E, Cullen M. Determinants of Isocyanate Exposures in Auto Body Repair and Refinishing Shops. Annals Of Work Exposures And Health 2004, 48: 393-403. PMID: 15148052, DOI: 10.1093/annhyg/meh021.Peer-Reviewed Original Research
2002
Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up
Redlich CA, Stowe MH, Coren BA, Wisnewski AV, Holm CT, Cullen MR. Diisocyanate‐exposed auto body shop workers: A one‐year follow‐up. American Journal Of Industrial Medicine 2002, 42: 511-518. PMID: 12439874, DOI: 10.1002/ajim.10143.Peer-Reviewed Original ResearchConceptsHealthy worker effectAuto body shop workersWorker effectHexamethylene diisocyanate exposureHistory of asthmaLower asthma prevalenceCross-sectional studyDiisocyanate exposureOccupational asthmaAsthma prevalenceImmunologic responseLow prevalenceAsthmaOne-yearHigh job turnover ratesShop workersEpisodic exposureSignificant differencesAuto body shopsPrevalenceEffect of HDISignificant changesExposureSymptomsIgG
2001
Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure.
Lemus R, Lukinskeine L, Bier ME, Wisnewski AV, Redlich CA, Karol MH. Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure. Environmental Health Perspectives 2001, 109: 1103-1108. PMID: 11712993, PMCID: PMC1240469, DOI: 10.1289/ehp.011091103.Peer-Reviewed Original ResearchConceptsHexamethylene diisocyanateHuman serum albuminLaser desorption timeMatrix-assisted laser desorption timeFlight mass spectrometryWorkplace air monitoringMass spectrometryDesorption timeDiisocyanateAdductsDevelopment of immunoassaysHSA antigenSerum albuminMicrotiter platesReactionAir monitoringHexamethylene diisocyanate exposurePpbAbsence of reactionSensitive bioassayNumerous samplesSpectrometryDiphenylPolyurethaneCoatingsSubclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers
Redlich C, Stowe M, Wisnewski A, Eisen E, Karol M, Lemus R, Holm C, Chung J, Sparer J, Liu Y, Woskie S, Appiah‐Pippim J, Gore R, Cullen M. Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers. American Journal Of Industrial Medicine 2001, 39: 587-597. PMID: 11385643, DOI: 10.1002/ajim.1058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAir Pollutants, OccupationalAnalysis of VarianceAsthmaAutomobilesChi-Square DistributionCross-Sectional StudiesCyanatesEpidemiologic StudiesFemaleHumansIsocyanatesMaleMiddle AgedOccupational DiseasesOccupational ExposurePaintStatistics, NonparametricSurveys and QuestionnairesConceptsAuto body shop workersDiisocyanate asthmaLymphocyte proliferationHost risk factorsShortness of breathShop workersMethacholine responsivenessMethacholine challengeChest tightnessDiisocyanate exposureOccupational asthmaImmunologic responseRisk factorsPhysiologic changesImmune responseEpidemiologic studiesSurveillance studyPhysiologic responsesAsthmaOvert casesSymptomsExposure dataEpisodic exposureAuto body shopsExposure
2000
Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo
WISNEWSKI A, SRIVASTAVA R, HERICK C, XU L, LEMUS R, CAIN H, MAGOSKI N, KAROL M, BOTTOMLY K, REDLICH C. Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo. American Journal Of Respiratory And Critical Care Medicine 2000, 162: 2330-2336. PMID: 11112159, DOI: 10.1164/ajrccm.162.6.2002086.Peer-Reviewed Original ResearchConceptsDiisocyanate-induced asthmaBiopsy samplesHuman lungHuman airway epithelial cellsBronchoalveolar lavage fluidAirway epithelial cellsEndobronchial biopsy samplesHuman skin biopsy samplesSkin biopsy samplesKeratin 18Epicutaneous exposureLavage fluidSkin proteinsVivo inhalationVivo exposureEpithelial cell proteinsGlucose-regulated proteinEpithelial cellsAsthmaLungExposureVitroVivoKeratinCell proteins
1997
Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate.
Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR. Airway isocyanate-adducts in asthma induced by exposure to hexamethylene diisocyanate. Scandinavian Journal Of Work, Environment & Health 1997, 23: 227-31. PMID: 9243734, DOI: 10.5271/sjweh.203.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAsthmaBiopsyBronchiCyanatesEpitheliumHumansImmunoglobulin EIsocyanatesMaleOccupational DiseasesOccupational ExposureConceptsHuman bronchial biopsiesHuman lung tissueExposure-disease relationshipsAirway eosinophilsAirway histologyEpithelial exposureMethacholine challengeBronchial biopsiesEndobronchial biopsyInflammatory changesClinical featuresAirway biopsiesIsocyanate asthmaLung tissueT cellsImmunohistochemical stainingAsthmaBiopsyExposure patternsBronchoscopyExposureAirwayPatientsEosinophilsHistology