2002
Diisocyanate asthma: clinical aspects and immunopathogenesis
Redlich CA, Karol MH. Diisocyanate asthma: clinical aspects and immunopathogenesis. International Immunopharmacology 2002, 2: 213-224. PMID: 11811926, DOI: 10.1016/s1567-5769(01)00174-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDiisocyanate asthmaProduction of polyurethanesChemical reactivityBiological nucleophilesClinical aspectsChemical interactionReactive chemicalsRoute of exposureDiisocyanateSimple diagnostic testOccupational asthmaEarly diseaseRespiratory tractNonimmunological mechanismsWorkplace exposuresAsthmaUseful markerReactionDiagnostic testsDiseasePathogenesisImmunopathogenesisBiomoleculesNucleophilesExposure
2001
Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure.
Lemus R, Lukinskeine L, Bier ME, Wisnewski AV, Redlich CA, Karol MH. Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure. Environmental Health Perspectives 2001, 109: 1103-1108. PMID: 11712993, PMCID: PMC1240469, DOI: 10.1289/ehp.011091103.Peer-Reviewed Original ResearchConceptsHexamethylene diisocyanateHuman serum albuminLaser desorption timeMatrix-assisted laser desorption timeFlight mass spectrometryWorkplace air monitoringMass spectrometryDesorption timeDiisocyanateAdductsDevelopment of immunoassaysHSA antigenSerum albuminMicrotiter platesReactionAir monitoringHexamethylene diisocyanate exposurePpbAbsence of reactionSensitive bioassayNumerous samplesSpectrometryDiphenylPolyurethaneCoatings