2025
Genomics yields biological and phenotypic insights into bipolar disorder
Lee B, Kim J, Lee Y, Kang J, Cheon M, Kim D, Aslan M, Harvey P, Huang G. Genomics yields biological and phenotypic insights into bipolar disorder. Nature 2025, 1-12. PMID: 39843750, DOI: 10.1038/s41586-024-08468-9.Peer-Reviewed Original ResearchFine-mappingGenetic architectureGenome-wide significant lociMulti-ancestry meta-analysisGenetic architecture of bipolar disorderRare variant signalsSignificant lociGenetic determinantsBipolar disorderVariant signalsLatino ancestryCell typesEast Asian cohortsPhenotypic insightsPathophysiology of bipolar disorderGenesMedium spiny neuronsBipolar disorder subtypesPatient ascertainmentAetiology of bipolar disorderGABAergic interneuronsSpiny neuronsAsian cohortGenomeGlobal burden
2019
Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci
Gelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB, Program D, Program M. Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. Biological Psychiatry 2019, 86: 365-376. PMID: 31151762, PMCID: PMC6919570, DOI: 10.1016/j.biopsych.2019.03.984.Peer-Reviewed Original ResearchConceptsAdditional genome-wide significant lociRisk lociWide association study (GWAS) analysisAssociation studiesGenome-wide significant lociGenome-wide association studiesGenetic correlationsWide association studyNovel risk lociAlcohol-related traitsStrong statistical supportSmoking-related traitsAdditional genomesSignificant lociPancreatic delta cellsChromosome 4Chromosome 11Protein productsChromosome 8Quantitative phenotypesMillion Veteran ProgramVeterans Affairs Million Veteran ProgramLociCell typesChromosome 17