Peritoneal B-1b and B-2 B-cells confer long-term protection from pneumococcal serotype 3 infection after vaccination with Prevnar-13 and are defective in sickle cell disease mice
Cotte C, Szczepanek S. Peritoneal B-1b and B-2 B-cells confer long-term protection from pneumococcal serotype 3 infection after vaccination with Prevnar-13 and are defective in sickle cell disease mice. Vaccine 2017, 35: 3520-3522. PMID: 28545925, DOI: 10.1016/j.vaccine.2017.05.039.Peer-Reviewed Original ResearchConceptsLong-term immunitySickle cell disease micePrevnar-13SCD miceDisease miceRecipient miceB cellsPneumococcal conjugate vaccineMice three timesB cell subsetsWild-type miceB-1aB-1a cellsSerotype 3 infectionB-1bConjugate vaccineWT miceLong-term protectionStreptococcus pneumoniaeSubset functionsMiceVaccinationWeek intervalsImmunityThree times