Brandon Lee, MD/PhD
Clinical FellowAbout
Research
Publications
2022
Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells
Williamson AJ, Jacobson R, van Praagh JB, Gaines S, Koo HY, Lee B, Chan WC, Weichselbaum R, Alverdy JC, Zaborina O, Shogan BD. Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells. Neoplasia 2022, 27: 100787. PMID: 35366466, PMCID: PMC8971311, DOI: 10.1016/j.neo.2022.100787.Peer-Reviewed Original ResearchConceptsE. faecalisTumor progressionCollagenolytic bacteriaPost-surgical recoveryHuman colon cancer specimensMurine colon cancer cell lineEnterococcus faecalisColon cancer developmentColon cancer specimensColon cancer cell linesCancer cell invasionCurative resectionCancer cell linesColon cancer cellsCancer specimensMouse modelIntestinal microbesCT26 cellsCancer developmentTumor developmentCollagenase productionTumor formationCancer cellsInvasive phenotypeCell invasion
2020
Staphylococcus aureus α-toxin suppresses antigen-specific T cell responses
Lee B, Olaniyi R, Kwiecinski JM, Wardenburg JB. Staphylococcus aureus α-toxin suppresses antigen-specific T cell responses. Journal Of Clinical Investigation 2020, 130: 1122-1127. PMID: 31873074, PMCID: PMC7269593, DOI: 10.1172/jci130728.Peer-Reviewed Original ResearchConceptsT cell responsesSkin infectionsCell responsesAntigen-specific T cell responsesOVA-specific T cell responsesT cell-mediated immunityS. aureusΑ-toxinAntigen-specific modelChicken egg OVACell-mediated immunityT cell memoryAntigen-specific memoryPrimary skin infectionsInvasive staphylococcal diseaseStaphylococcus aureus α-toxinDevelopment of immunityΑ-toxin expressionAureus α-toxinProtective immunityInvasive infectionsLeading causeLoss of DCsStaphylococcal diseaseLong-term protection
2018
A common approach to toxin specificity
Lee B, Bubeck Wardenburg J. A common approach to toxin specificity. Nature Microbiology 2018, 3: 644-645. PMID: 29795538, DOI: 10.1038/s41564-018-0173-z.Peer-Reviewed Original Research