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Stephanie Halene, MD, Dr Med

Arthur H and Isabel Bunker Professor of Medicine (Hematology) and Professor of Pathology; Chief, Department of Internal Medicine, Section of Hematology; Director, DeLuca Center for Innovation in Hematology Research, Yale Cancer Center; Assistant Medical Director CRSL, Yale Cancer Center; Chief, Yale Cancer Center, Division of Translational Hematology

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Stephanie Halene, MD, Dr Med

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Dr. Halene is a physician-scientist who received her MD degree at Eberhardt-Karls-University in Tübingen, Germany. She subsequently completed a postdoctoral fellowship in the laboratory of Donald B. Kohn at CHLA in Los Angeles and her residency in internal medicine in the traditional program at Yale New Haven Hospital. She completed her fellowship in hematology/oncology at Yale and joined the ladder faculty at YSM as an assistant professor in 2010. At that time she was also named director of the Hematology Tissue Bank for Yale Cancer Center. She was promoted to associate professor in 2016 and subsequently served as interim chief of the Section of Hematology prior to her appointment as chief of that section in 2020.

Her laboratory studies hematopoiesis and myelopoiesis and in particular how mutations in splicing factors and perturbations in RNA modifications contribute to hematologic malignancies such as myelodysplasia and leukemia. Dr. Halene, in collaboration with the Flavell laboratory in the YSM Department of Immunobiology, has developed the first efficient xenotransplantation model in humanized mice to study myelodysplasia and enable testing of novel drug treatments. Dr. Halene’s research has garnered significant attention from the international community, as evidenced by numerous invited speaking engagements, an invitation to serve as a section editor on myeloid malignancies for a major journal, and publications in top tier journals in her field. In 2015 she was presented with the Sir William Osler Young Investigator Award and in 2019 was elected a member of the Interurban Clinical Club.

Dr. Halene is director of the DeLuca Center for Innovation in Hematology Research. Through generous funding from The Frederick A. DeLuca Foundation, the center has established a comprehensive biospecimen bank, awarded pilot and career development grant funding to advance cutting-edge discoveries in hematologic malignancies and classical hematologic disorders.

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Education & Training

  • Fellow
    Yale University School of Medicine (2006)
  • Resident
    Yale-New Haven Hospital (2002)
  • Postdoctoral Associate
    Childrens Hospital Los Angeles (2000)
  • Dr Med
    Eberhard-Karls-Universitat Tubingen (1997)
  • Resident
    Eberhard-Karls-University (1997)
  • MD
    Eberhard-Karls-Universitat Tubingen (1995)

Honors & Recognition

AwardAwarding OrganizationDate
Elected MemberConnecticut Academy of Science and Engineering2024
2022 Recipient of the "2nd Century of Women: Emerging Leaders in Internal Medicine" AwardDepartment of Internal Medicine2022
Elected MemberInterurban Clinical Club2019
Sir William Osler Young Investigator AwardInterurban Clinical Club2015
Career Development AwardClaude D. Pepper Older Americans Independence Center2010
T32 Research FellowNIH2003
ScholarshipAmerican Heart Association1993
ScholarGerman Academic Exchange Service (DAAD)1990
ScholarStudienstiftung des Deutschen Volkes1988

Professional Service

External Advisory Board, Cellular & Molecular Biology Masters Program, University of New HavenBoard Member2021 - Present
Music Haven. A non-profit organization providing free string instrument lesson and music education to children in New Haven Public Schools (, Board of Directors2014 - 2021

Departments & Organizations