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The Halene Laboratory focuses on the study of myeloid malignancies and hematopoiesis. In particular we seek to understand the role of mutations in splicing factors, present in nearly 50% of patient with Myelodysplasia (MDS) and Acute Myeloid Leukemia (AML). In addition, we seek to establish a “co-clinical” model for MDS and AML with the goal to facilitate the translation of improved, less toxic, and more efficient treatments for MDS and AML into the clinic.