2008
Long‐Term Treatment with Buprenorphine/Naloxone in Primary Care: Results at 2–5 Years
Fiellin DA, Moore BA, Sullivan LE, Becker WC, Pantalon MV, Chawarski MC, Barry DT, O'Connor PG, Schottenfeld RS. Long‐Term Treatment with Buprenorphine/Naloxone in Primary Care: Results at 2–5 Years. American Journal On Addictions 2008, 17: 116-120. PMID: 18393054, DOI: 10.1080/10550490701860971.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineCombined Modality TherapyCounselingCross-Sectional StudiesDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationFemaleFollow-Up StudiesHeroin DependenceHumansLong-Term CareMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPatient DropoutsPrimary Health CareSubstance Abuse DetectionTreatment OutcomeConceptsOpioid-dependent patientsAdverse eventsSerum transaminasesBuprenorphine/naloxone treatmentSerious adverse eventsBuprenorphine/naloxoneLong-term outcomesOffice-based treatmentIllicit drug useOpioid useClinical stabilityNaloxone treatmentPrimary outcomePatient satisfactionPrimary careTerm treatmentDrug useUrine samplesPatientsTreatmentTransaminaseOutcomesYearsModerate levelsPercent
2007
Primary Care Office-based Buprenorphine Treatment: Comparison of Heroin and Prescription Opioid Dependent Patients
Moore BA, Fiellin DA, Barry DT, Sullivan LE, Chawarski MC, O’Connor P, Schottenfeld RS. Primary Care Office-based Buprenorphine Treatment: Comparison of Heroin and Prescription Opioid Dependent Patients. Journal Of General Internal Medicine 2007, 22: 527-530. PMID: 17372805, PMCID: PMC1829433, DOI: 10.1007/s11606-007-0129-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidBuprenorphineFemaleHeroinHeroin DependenceHumansMaleOffice VisitsOpioid-Related DisordersPrimary Health CareConceptsPrescription opioid useOpioid useOnly patientsPrescription opioidsTreatment outcomesBuprenorphine/naloxone maintenanceBuprenorphine/naloxone treatmentOpioid-negative urine samplesPrescription opioid-dependent patientsHepatitis C antibodyDrug treatment historyOpioid-dependent patientsPrimary care officesOffice-based settingClinical characteristicsBuprenorphine treatmentNaloxone treatmentBuprenorphine/Opioid dependenceCare officesDependent patientsTreatment responseC antibodyHeroin usePatients
2005
Methods of Detoxification and Their Role in Treating Patients With Opioid Dependence
O’Connor P. Methods of Detoxification and Their Role in Treating Patients With Opioid Dependence. JAMA 2005, 294: 961-963. PMID: 16118388, DOI: 10.1001/jama.294.8.961.Peer-Reviewed Original Research
2002
Office-Based Treatment of Opioid-Dependent Patients
Fiellin DA, O'Connor PG. Office-Based Treatment of Opioid-Dependent Patients. New England Journal Of Medicine 2002, 347: 817-823. PMID: 12226153, DOI: 10.1056/nejmcp013579.Peer-Reviewed Original ResearchTreatment of heroin dependence with buprenorphine in primary care
Fiellin DA, Pantalon MV, Pakes JP, O'Connor PG, Chawarski M, Schottenfeld RS. Treatment of heroin dependence with buprenorphine in primary care. The American Journal Of Drug And Alcohol Abuse 2002, 28: 231-241. PMID: 12014814, DOI: 10.1081/ada-120002972.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, SublingualAdultAmbulatory CareBuprenorphineCombined Modality TherapyConnecticutCounselingDose-Response Relationship, DrugDrug Administration ScheduleFeasibility StudiesFemaleHeroin DependenceHumansMaleMiddle AgedPrimary Health CareSocial SupportTreatment OutcomeUrban PopulationConceptsUrine toxicologyHeroin dependencePrimary careBrief counselingUrine toxicology testsHeroin-dependent patientsPrimary care settingPrimary care centersUrban medical centerBuprenorphine maintenancePrimary outcomeDependent patientsCare centerClinical trialsCare settingsMedical CenterEffective treatmentTreatment retentionBuprenorphinePatientsPotential efficacyToxicology testsMaintenance phaseWeeksCare
2000
Pharmacologic treatment of heroin-dependent patients.
O'Connor P, Fiellin D. Pharmacologic treatment of heroin-dependent patients. Annals Of Internal Medicine 2000, 133: 40-54. PMID: 10877739, DOI: 10.7326/0003-4819-133-1-200007040-00008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHeroin dependenceHeroin-dependent patientsDrug treatment settingsBehavioral health problemsOpioid withdrawalPharmacologic treatmentMethadone maintenanceHeroin usePhysician's officeTreatment approachesTreatment settingsHealth problemsPatientsRelapse preventionTreatmentPhysiciansAcetylmethadolBuprenorphineInternistsReferralDiagnosisAlternative sitesPreventionThrice-weekly versus daily buprenorphine maintenance
Schottenfeld R, Pakes J, O’Connor P, Chawarski M, Oliveto A, Kosten T. Thrice-weekly versus daily buprenorphine maintenance. Biological Psychiatry 2000, 47: 1072-1079. PMID: 10862807, DOI: 10.1016/s0006-3223(99)00270-x.Peer-Reviewed Original ResearchConceptsSublingual buprenorphineMaintenance treatmentSelf-reported illicit drug useDrug useOpioid agonist maintenance treatmentOpioid-positive urine testsAgonist maintenance treatmentDaily clinic attendanceDaily sublingual buprenorphineThrice-weekly dosingOpioid-dependent patientsUrine toxicology testsSignificant differencesIllicit drug useSelf-reported numberBuprenorphine maintenanceClinic attendanceWeekly doseIllicit opioidsMedication complianceThrice weeklyUrine testsOutcome measuresBuprenorphineCounseling attendance
1999
Hypersensitivity pneumonitis induced by intranasal heroin use
Karne S, D’Ambrosio C, Einarsson O, O’Connor P. Hypersensitivity pneumonitis induced by intranasal heroin use. The American Journal Of Medicine 1999, 107: 387-390. PMID: 10527043, DOI: 10.1016/s0002-9343(99)00244-2.Peer-Reviewed Original Research
1997
Three methods of opioid detoxification in a primary care setting. A randomized trial.
O'Connor PG, Carroll KM, Shi JM, Schottenfeld RS, Kosten TR, Rounsaville BJ. Three methods of opioid detoxification in a primary care setting. A randomized trial. Annals Of Internal Medicine 1997, 127: 526-30. PMID: 9313020, DOI: 10.7326/0003-4819-127-7-199710010-00004.Peer-Reviewed Original ResearchConceptsPrimary care settingOpioid detoxificationCare settingsBuprenorphine groupWithdrawal symptomsDouble-blind clinical trialOpioid-dependent patientsHeroin-dependent patientsPrimary care clinicsWithdrawal symptom scoresSevere withdrawal symptomsDrug treatment programsSubstance abuse treatmentNaltrexone groupCare clinicsSymptom scoresPharmacologic protocolClinical trialsTreatment protocolClonidineTreatment retentionBuprenorphineNaltrexoneTreatment programAbuse treatment
1996
The substance-using human immunodeficiency virus patient: Approaches to outpatient management
O'Connor P, Samet J. The substance-using human immunodeficiency virus patient: Approaches to outpatient management. The American Journal Of Medicine 1996, 101: 435-444. PMID: 8873515, DOI: 10.1016/s0002-9343(96)00200-8.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusPrimary careHuman immunodeficiency virus (HIV) patientsAbuse treatmentPrimary care physiciansEffective primary careMaintenance of abstinenceSubstance use disordersLong-term abstinenceSubstance abuse treatmentSubstance abuse programsDrug abuse treatmentOutpatient managementVirus patientsHIV infectionWithdrawal syndromeCare physiciansMedical managementImmunodeficiency virusSubstance use historiesCommon complaintDrug treatmentUse disordersDrug useSpecific drugsA Pilot Study of Primary-Care—Based Buprenorphine Maintenance for Heroin Dependence
O'Connor P, Oliveto A, Shi J, Triffleman E, Carroll K, Kosten T, Rounsaville B. A Pilot Study of Primary-Care—Based Buprenorphine Maintenance for Heroin Dependence. The American Journal Of Drug And Alcohol Abuse 1996, 22: 523-531. PMID: 8911590, DOI: 10.3109/00952999609001678.Peer-Reviewed Original ResearchConceptsPrimary care providersHeroin dependenceBuprenorphine maintenancePilot studyOpioid maintenanceOpen-label pilot studyUrine toxicology dataPrimary care settingDrug treatment settingsSelf-help meetingsPrimary careMajority of urinesTreatment settingsPatientsToxicology dataBuprenorphineTreatmentOpioidsMethadoneProvidersStudySettingDosesMonthsUrine
1994
HIV infection and cocaine use in methadone maintained and untreated intravenous drug users
Meandzija B, O'Connor P, Fitzgerald B, Rounsaville B, Kosten T. HIV infection and cocaine use in methadone maintained and untreated intravenous drug users. Drug And Alcohol Dependence 1994, 36: 109-113. PMID: 7851277, DOI: 10.1016/0376-8716(94)90092-2.Peer-Reviewed Original ResearchConceptsIntravenous drug usersMethadone maintenance treatmentMethadone maintenance programHIV infectionCocaine useMore cocaine useMaintenance treatmentRisk factorsDrug usersMethadone maintenance treatment groupHuman immunodeficiency virus (HIV) transmissionAfrican AmericansMaintenance treatment groupNon-infected subjectsInjection frequencyHIV-negativeHIV testingDrug injectionStratified analysisTreatment groupsTotal cocaineHIVRisk behaviorsGreater riskInfection