2021
Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV
McGinnis KA, Tate JP, Bryant KJ, Justice AC, O’Connor P, Rodriguez-Barradas MC, Crystal S, Cutter CJ, Hansen NB, Maisto SA, Marconi VC, Williams EC, Cook RL, Gordon AJ, Gordon KS, Eyawo O, Edelman EJ, Fiellin DA. Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV. AIDS And Behavior 2021, 26: 786-794. PMID: 34542779, DOI: 10.1007/s10461-021-03438-y.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingBiomarkersGlycerophospholipidsHIV InfectionsHumansMaleMiddle AgedSelf Report
2020
Validating Self‐Reported Unhealthy Alcohol Use With Phosphatidylethanol (PEth) Among Patients With HIV
Eyawo O, Deng Y, Dziura J, Justice AC, McGinnis K, Tate JP, Rodriguez‐Barradas M, Hansen NB, Maisto SA, Marconi VC, O’Connor P, Bryant K, Fiellin DA, Edelman EJ. Validating Self‐Reported Unhealthy Alcohol Use With Phosphatidylethanol (PEth) Among Patients With HIV. Alcohol Clinical And Experimental Research 2020, 44: 2053-2063. PMID: 33460225, PMCID: PMC8856627, DOI: 10.1111/acer.14435.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useSignificant alcohol useHeavy drinking daysAlcohol use disorderTimeline FollowbackAlcohol useSelf-reported alcohol useNumber of drinksClinical trialsRisk drinkingUse disordersDrinking daysBiomarker-based evidenceSample of PWHDrinks/dayMean numberSelf-reported alcohol consumptionMagnitude of associationBlood spot samplesLiver diseasePEth levelsTLFB interviewAlcohol consumptionLogistic regressionPatients
2019
Integrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial. Journal Of Substance Use And Addiction Treatment 2019, 106: 97-106. PMID: 31540617, PMCID: PMC7244228, DOI: 10.1016/j.jsat.2019.08.007.Peer-Reviewed Original ResearchIntegrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial. The Lancet HIV 2019, 6: e509-e517. PMID: 31109915, PMCID: PMC7161741, DOI: 10.1016/s2352-3018(19)30076-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlcohol DrinkingAlcoholismCounselingFemaleHIV InfectionsHumansMaleMiddle AgedTreatment OutcomeUnited StatesYoung AdultConceptsAlcohol use disorderWeek 24Use disordersAlcohol treatmentAdverse eventsNumber of drinksTreatment medicationsPhysician managementAlcohol abuseMental Disorders-IV criteriaAlcohol-related careFormal alcohol treatmentKey exclusion criteriaTimeline followback methodMotivational enhancement therapyTreat populationHIV clinicHIV outcomesPrimary outcomeSpecialty referralsMean ageUS National InstitutesWeek 4Medical conditionsExclusion criteria
2016
Protocol for three parallel multi-site stepped care effectiveness studies for unhealthy alcohol use in HIV-positive patients
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Fiellin LE, O'Connor PG, Bedimo R, Gibert C, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Justice AC, Bryant KJ, Fiellin DA. Protocol for three parallel multi-site stepped care effectiveness studies for unhealthy alcohol use in HIV-positive patients. Contemporary Clinical Trials 2016, 52: 80-90. PMID: 27876616, PMCID: PMC5253227, DOI: 10.1016/j.cct.2016.11.008.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useAlcohol use disorderHIV-positive patientsMotivational enhancement therapyAlcohol useWeek 12Risk drinkingWeek 4Effective evidence-based treatmentsInfectious disease clinicHIV-positive individualsModerate alcohol useEvidence-based treatmentsParticipants meeting criteriaImplementation of interventionsVACS IndexHIV careSecondary outcomesCare trialsDisease clinicHIV morbidityPrimary outcomeAlcohol pharmacotherapyInitial treatmentLiver diseaseImplementation of integrated stepped care for unhealthy alcohol use in HIV clinics
Edelman EJ, Hansen NB, Cutter CJ, Danton C, Fiellin LE, O’Connor P, Williams EC, Maisto SA, Bryant KJ, Fiellin DA. Implementation of integrated stepped care for unhealthy alcohol use in HIV clinics. Addiction Science & Clinical Practice 2016, 11: 1. PMID: 26763048, PMCID: PMC4711105, DOI: 10.1186/s13722-015-0048-z.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useHIV clinicAlcohol usePatient motivationIntervention characteristicsInner settingHIV treatment settingsImplementation Research domainsModel of careCharacteristics of individualsAddiction psychiatristsCare modelCFIR frameworkTreatment settingsCFIR domainsMultidisciplinary teamClinicConsolidated FrameworkImplementation themesPatientsProvider perspectivesCareEffective counselingSocial workersIntervention
2014
Predictors of Abstinence from Heavy Drinking During Treatment in COMBINE and External Validation in PREDICT
Gueorguieva R, Wu R, O'Connor PG, Weisner C, Fucito LM, Hoffmann S, Mann K, O'Malley SS. Predictors of Abstinence from Heavy Drinking During Treatment in COMBINE and External Validation in PREDICT. Alcohol Clinical And Experimental Research 2014, 38: 2647-2656. PMID: 25346505, PMCID: PMC4397985, DOI: 10.1111/acer.12541.Peer-Reviewed Original ResearchAcamprosateAge FactorsAlcohol AbstinenceAlcohol DeterrentsAlcohol DrinkingBehavior TherapyCombined Modality TherapyControlled Clinical Trials as TopicDecision TreesGamma-GlutamyltransferaseGermanyGoalsHumansLogistic ModelsMiddle AgedNaltrexonePredictive Value of TestsRandomized Controlled Trials as TopicReproducibility of ResultsTaurineTime FactorsTreatment OutcomeUnited States
2012
Development of a scale to measure practitioner adherence to a brief intervention in the emergency department
Pantalon MV, Martino S, Dziura J, Li FY, Owens PH, Fiellin DA, O'Connor PG, D'Onofrio G. Development of a scale to measure practitioner adherence to a brief intervention in the emergency department. Journal Of Substance Use And Addiction Treatment 2012, 43: 382-388. PMID: 23021098, PMCID: PMC3661016, DOI: 10.1016/j.jsat.2012.08.011.Peer-Reviewed Original ResearchConceptsBrief Negotiation InterviewBrief interventionTwo-factor structureExcellent internal consistencyGood construct validityDiscriminant validityPredictive validityEmergency departmentExcellent inter-rater reliabilityPsychometric propertiesEight-itemConstruct validityHazardous drinkingInternal consistencyEmergency department patientsPractitioner adherenceInter-rater reliabilityDepartment patientsAdherence ScaleClinical practiceValidityInterventionSkillsAdherenceScaleA Brief Intervention Reduces Hazardous and Harmful Drinking in Emergency Department Patients
D'Onofrio G, Fiellin DA, Pantalon MV, Chawarski MC, Owens PH, Degutis LC, Busch SH, Bernstein SL, O'Connor PG. A Brief Intervention Reduces Hazardous and Harmful Drinking in Emergency Department Patients. Annals Of Emergency Medicine 2012, 60: 181-192. PMID: 22459448, PMCID: PMC3811141, DOI: 10.1016/j.annemergmed.2012.02.006.Peer-Reviewed Original ResearchConceptsBrief Negotiation InterviewStandard careEmergency department patientsBrief interventionAlcohol consumptionDepartment patientsHarmful drinkersDrinking outcomesHarmful drinkingAssessment groupStandard care groupAdult ED patientsNegative health behaviorsSecondary outcomesPrimary outcomeED patientsCare groupED settingTelephone boosterBooster groupBinge episodesHealth behaviorsPatientsAlcohol useCare
2011
Medications for unhealthy alcohol use: across the spectrum.
O'Malley SS, O'Connor PG. Medications for unhealthy alcohol use: across the spectrum. Alcohol Research 2011, 33: 300-12. PMID: 23580015, PMCID: PMC3860540.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useSpecialty careCare settingsAlcohol useAdvent of pharmacotherapyPrimary care providersPrimary care settingSpectrum of careHealth care settingsPrimary careCare providersHazardous drinkersEarly interventionExcessive drinkingCareAlcohol problemsTreatmentMedicationsPharmacotherapyPatientsCliniciansPrevalenceSettingDrinkers
2008
Brief Intervention for Hazardous and Harmful Drinkers in the Emergency Department
D'Onofrio G, Pantalon MV, Degutis LC, Fiellin DA, Busch SH, Chawarski MC, Owens PH, O'Connor PG. Brief Intervention for Hazardous and Harmful Drinkers in the Emergency Department. Annals Of Emergency Medicine 2008, 51: 742-750.e2. PMID: 18436340, PMCID: PMC2819119, DOI: 10.1016/j.annemergmed.2007.11.028.Peer-Reviewed Original ResearchConceptsBrief Negotiation InterviewBinge-drinking episodesHarmful drinkersBrief interventionDischarge instructionsPatients 18 yearsRandomized clinical trialsEmergency department settingMean numberInterview groupAlcoholism guidelinesBaseline characteristicsUrban EDAlcohol ingestionED patientsEmergency departmentClinical trialsDepartment settingAlcohol abuseAlcohol consumptionEmergency practitionersTreatment servicesHarmful drinkingMonthsDrinkers
2007
Smoking Status as a Clinical Indicator for Alcohol Misuse in US Adults
McKee SA, Falba T, O’Malley S, Sindelar J, O’Connor P. Smoking Status as a Clinical Indicator for Alcohol Misuse in US Adults. JAMA Internal Medicine 2007, 167: 716-721. PMID: 17420431, PMCID: PMC2869385, DOI: 10.1001/archinte.167.7.716.Peer-Reviewed Original ResearchConceptsClinical care guidelinesSmoking statusPositive predictive valueClinical indicatorsAlcohol misuseUS adultsPositive likelihood ratioCurrent smokingCare guidelinesOdds ratioAlcohol diagnosisAssociated Disabilities Interview Schedule-IVPredictive valueHazardous drinkingPrimary care settingAlcohol-related diagnosesConfidence intervalsAlcohol use disorderNational Epidemiological SurveyAlcohol use diagnosisHazardous drinking behaviorLikelihood ratioOccasional smokersPrimary careDaily smokers
2005
Problem Drinkers: Find Them, Keep Them, Don't Lose Them—Treat Them
O'Connor PG. Problem Drinkers: Find Them, Keep Them, Don't Lose Them—Treat Them. Journal Of General Internal Medicine 2005, 20: 96-97. PMID: 15693936, PMCID: PMC1490046, DOI: 10.1111/j.1525-1497.2005.04005.x.Peer-Reviewed Original Research
2003
Measuring Alcohol Consumption Among Older Adults: A Comparison of Available Methods
Reid MC, Tinetti ME, O'Connor PG, Kosten TR, Concato J. Measuring Alcohol Consumption Among Older Adults: A Comparison of Available Methods. American Journal On Addictions 2003, 12: 211-219. PMID: 12851017, DOI: 10.1111/j.1521-0391.2003.tb00649.x.Peer-Reviewed Original ResearchConceptsAlcohol exposureVA primary care clinicsOlder adultsCommunity-dwelling Medicare beneficiariesQuantity-frequency questionsPrimary care clinicsAlcohol Use Disorders Identification TestPercentage of participantsDisorders Identification TestCare clinicsAlcohol historyCurrent drinkersOlder veteransMedicare beneficiariesAlcohol consumptionElderly adultsOlder personsLevel of agreementAlcohol useIdentification TestKappa valuesAdultsAlcohol measuresConcordanceExposure
2002
The Health-Related Effects of Alcohol Use in Older Persons: A Systematic Review
Reid MC, Boutros NN, O'Connor PG, Cadariu A, Concato J. The Health-Related Effects of Alcohol Use in Older Persons: A Systematic Review. Substance Abuse 2002, 23: 149-164. DOI: 10.1023/a:1019896822588.Peer-Reviewed Original ResearchConceptsCause mortalityCognitive impairmentExposure statusFunctional disabilityAlcohol useOlder adultsFunctional impairmentMiddle-aged adult populationParticipants 60 yearsYears of ageEnglish-language studiesExposure-outcome associationsImportant confounding factorsHealth-related effectsEffects of alcoholMagnitude of riskCohort studySubstantial morbidityPercentage of studiesFormer drinkersProspective studyMean ageAlcohol exposureMethodologic qualityOutcome measuresThe Health–Related Effects of Alcohol Use in Older Persons: A Systematic Review
Reid M, Boutros N, O'Connor P, Cadariu A, Concato J. The Health–Related Effects of Alcohol Use in Older Persons: A Systematic Review. Substance Abuse 2002, 23: 149-164. PMID: 12444348, DOI: 10.1080/08897070209511485.Peer-Reviewed Original ResearchConceptsCause mortalityCognitive impairmentExposure statusFunctional disabilityAlcohol useOlder adultsFunctional impairmentMiddle-aged adult populationParticipants 60 yearsYears of ageEnglish-language studiesExposure-outcome associationsImportant confounding factorsHealth-related effectsEffects of alcoholMagnitude of riskCohort studySubstantial morbidityPercentage of studiesFormer drinkersProspective studyMean ageAlcohol exposureMethodologic qualityOutcome measuresUse of Alcohol, Illicit Drugs, and Tobacco among Characters on Prime–Time Television
Long JA, O'Connor PG, Gerbner G, Concato J. Use of Alcohol, Illicit Drugs, and Tobacco among Characters on Prime–Time Television. Substance Abuse 2002, 23: 95-103. PMID: 12444354, DOI: 10.1080/08897070209511479.Peer-Reviewed Original Research
2000
New therapies for alcohol problems: application to primary care
Fiellin D, Reid M, O’Connor P. New therapies for alcohol problems: application to primary care. The American Journal Of Medicine 2000, 108: 227-237. PMID: 10723977, DOI: 10.1016/s0002-9343(99)00448-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAlcohol consumptionNew therapiesAlcohol dependenceAlcohol problemsPrimary care physiciansRecent clinical trialsNew treatment strategiesTwelve-step facilitationMotivational enhancement therapyPharmacologic therapyCare physiciansLongitudinal carePrimary careClinical trialsTreatment strategiesDrinking reductionsPatientsPsychosocial counselingBrief interventionHarmful drinkingTherapyPhysician effortEnhancement therapyCognitive behavioralCurrent review
1999
Hazardous and Harmful Alcohol Consumption in Primary Care
Reid MC, Fiellin DA, O'Connor PG. Hazardous and Harmful Alcohol Consumption in Primary Care. JAMA Internal Medicine 1999, 159: 1681-1689. PMID: 10448769, DOI: 10.1001/archinte.159.15.1681.Peer-Reviewed Original ResearchConceptsPrimary care settingAlcohol Use Disorders Identification TestMichigan Alcoholism Screening TestAdverse health eventsAlcohol consumptionHarmful drinkingCare settingsHazardous drinkingRecent large prospective studyHealth eventsLarge prospective studiesHarmful alcohol consumptionAlcoholism Screening TestDisorders Identification TestHealth-related effectsAdverse eventsHemorrhagic strokeRandomized trialsProspective studyPrimary careCAGE questionnaireBreast cancerAlcohol abuseTreatment approachesPrevalence estimatesMeasurement of compliance with naltrexone in the treatment of alcohol dependence: research and clinical implications.
Namkoong K, Farren CK, O'Connor PG, O'Malley SS. Measurement of compliance with naltrexone in the treatment of alcohol dependence: research and clinical implications. The Journal Of Clinical Psychiatry 1999, 60: 449-53. PMID: 10453799, DOI: 10.4088/jcp.v60n0706.Peer-Reviewed Original ResearchConceptsMedication Event Monitoring SystemMedication compliancePill countAlcohol dependenceOpen-label studyPill-taking behaviorSample of patientsEvent Monitoring SystemMeasurement of complianceEstimates of complianceCompliant groupPharmacotherapy researchTreatment outcomesClinical utilityCompliance rateNaltrexoneClinical implicationsOverall outcomeDrinking outcomesPatientsMEMS dataOutcomesCountTreatmentCompliance