2000
Naltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects
O'Malley S, Krishnan-Sarin S, Farren C, O'Connor P. Naltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects. Journal Of Clinical Psychopharmacology 2000, 20: 69-76. PMID: 10653211, DOI: 10.1097/00004714-200002000-00012.Peer-Reviewed Original ResearchConceptsRisk of nauseaEndogenous opioid systemIntensity of drinkingSevere nauseaOpioid systemAlcohol useLight drinkersMost alcoholic patientsWeeks of naltrexoneOpen-label trialLong-term alcohol usePoor medication compliancePretreatment patient characteristicsLogistic regression analysisAlcohol-dependent subjectsDays of abstinenceDuration of abstinenceSignificant nauseaPatient characteristicsClinical predictorsEndogenous opioidsMedication complianceAlcoholic patientsNaltrexone doseRisk factors
1997
A Preliminary Investigation of the Management of Alcohol Dependence With Naltrexone by Primary Care Providers
O’Connor P, Farren C, Rounsaville B, O’Malley S. A Preliminary Investigation of the Management of Alcohol Dependence With Naltrexone by Primary Care Providers. The American Journal Of Medicine 1997, 103: 477-482. PMID: 9428830, DOI: 10.1016/s0002-9343(97)00271-4.Peer-Reviewed Original ResearchConceptsPrimary care providersCare providersGamma-glutamyl transferaseAlcohol dependenceDays abstinentHeavy drinkingSerum gamma-glutamyl transferaseCare treatment modelCompletion of treatmentPercent days abstinentAlcohol-dependent subjectsAlcohol-dependent individualsNaltrexone therapyNumber of drinksPrimary outcomeLiver enzymesPatient ratingsNew patientsGlutamyl transferaseNaltrexoneProvider ratingsBaselineTreatment modelTreatmentDrinking behavior