2022
Blue light potentiates safety and bactericidal activity of p-Toluquinone
Wang S, Wong K, Li Y, Ishii M, Li X, Wei L, Lu M, Wu M. Blue light potentiates safety and bactericidal activity of p-Toluquinone. Journal Of Photochemistry And Photobiology B Biology 2022, 230: 112427. PMID: 35338920, DOI: 10.1016/j.jphotobiol.2022.112427.Peer-Reviewed Original ResearchConceptsMultiple drug resistanceBacterial infectionsBactericidal activityE. coli infectionHospital-acquired infectionsMDR bacterial infectionsMDR Escherichia coliNon-specific natureColi infectionCombinatory therapyOxygen species generationInfectionScratch woundBrief exposureEnterococcus faecalisSpecies generationKilling efficacyOpposite effectRecurrenceTherapy
2021
Bacteria-specific phototoxic reactions triggered by blue light and phytochemical carvacrol
Lu M, Wang S, Wang T, Hu S, Bhayana B, Ishii M, Kong Y, Cai Y, Dai T, Cui W, Wu M. Bacteria-specific phototoxic reactions triggered by blue light and phytochemical carvacrol. Science Translational Medicine 2021, 13 PMID: 33408183, DOI: 10.1126/scitranslmed.aba3571.Peer-Reviewed Original ResearchConceptsPhototoxic reactionsMammalian cellsMultidrug-resistant bacterial infectionsSkin wound infectionThird-degree burn woundsAdverse eventsBacterial colony-forming unitsWound infectionCombined therapyAntibiotic susceptibilityMDR bacteriaBacterial infectionsBurn woundsSingle treatmentColony-forming unitsBlue lightArray of bacteriaInfectionWound healingHost DNABacterial resistanceMature biofilmsOxygen speciesSuccessive passagesTreatment
2018
Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways
Yuan X, Han L, Fu P, Zeng H, Lv C, Chang W, Runyon R, Ishii M, Han L, Liu K, Fan T, Zhang W, Liu R. Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways. Laboratory Investigation 2018, 98: 783-798. PMID: 29463877, DOI: 10.1038/s41374-018-0025-8.Peer-Reviewed Original ResearchMeSH KeywordsAcroleinAnimalsCell MovementCell ProliferationCells, CulturedHuman Umbilical Vein Endothelial CellsHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLNeovascularization, PhysiologicNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasePhthalazinesPyridinesUp-RegulationVascular Endothelial Growth Factor AWound HealingZebrafishConceptsHuman umbilical vein endothelial cellsMAPK signaling pathwaysSignaling pathwaysMitogen-activated protein kinase pathwayProtein kinase pathwaySmall non-peptide moleculesVascular endothelial growth factor receptorPI3K/AktIntersegmental vesselsGrowth factor receptorVascular endothelial growth factorKinase pathwayUmbilical vein endothelial cellsVein endothelial cellsPI3KFactor receptorTube formationNon-peptide moleculesEndothelial growth factor receptorPathway