Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways
Yuan X, Han L, Fu P, Zeng H, Lv C, Chang W, Runyon R, Ishii M, Han L, Liu K, Fan T, Zhang W, Liu R. Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways. Laboratory Investigation 2018, 98: 783-798. PMID: 29463877, DOI: 10.1038/s41374-018-0025-8.Peer-Reviewed Original ResearchMeSH KeywordsAcroleinAnimalsCell MovementCell ProliferationCells, CulturedHuman Umbilical Vein Endothelial CellsHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLNeovascularization, PhysiologicNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasePhthalazinesPyridinesUp-RegulationVascular Endothelial Growth Factor AWound HealingZebrafishConceptsHuman umbilical vein endothelial cellsMAPK signaling pathwaysSignaling pathwaysMitogen-activated protein kinase pathwayProtein kinase pathwaySmall non-peptide moleculesVascular endothelial growth factor receptorPI3K/AktIntersegmental vesselsGrowth factor receptorVascular endothelial growth factorKinase pathwayUmbilical vein endothelial cellsVein endothelial cellsPI3KFactor receptorTube formationNon-peptide moleculesEndothelial growth factor receptorPathway