2008
Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis
Wang Z, Dong X, Li Z, Smith JD, Wu D. Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis. Prostaglandins And Other Lipid Mediators 2008, 87: 9-13. PMID: 18502673, PMCID: PMC3644862, DOI: 10.1016/j.prostaglandins.2008.04.001.Peer-Reviewed Original Research
2005
P-Rex1 Is a Primary Rac2 Guanine Nucleotide Exchange Factor in Mouse Neutrophils
Dong X, Mo Z, Bokoch G, Guo C, Li Z, Wu D. P-Rex1 Is a Primary Rac2 Guanine Nucleotide Exchange Factor in Mouse Neutrophils. Current Biology 2005, 15: 1874-1879. PMID: 16243036, DOI: 10.1016/j.cub.2005.09.014.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCaseinsCell LineChemotaxisCloning, MolecularEnzyme ActivationGene TargetingGuanine Nucleotide Exchange FactorsHumansImmunoprecipitationMiceMice, KnockoutNeuropeptidesNeutrophilsN-Formylmethionine Leucyl-PhenylalanineProtein TransportRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSuperoxidesConceptsP-Rex1Exchange factorGuanine nucleotide exchange factorsNucleotide exchange factorsRegulation of RacF-actin formationMouse neutrophilsSmall GTPasesRho familyRac activityApparent high affinityRac activatorActin formationRac1 activationRac2 activationCdc42Mouse linesRacRac2RhoAMigration rateRegulationHigh affinityLeukocyte chemoattractantsGTPasesRegulation of PTEN by Rho small GTPases
Li Z, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D. Regulation of PTEN by Rho small GTPases. Nature Cell Biology 2005, 7: 399-404. PMID: 15793569, DOI: 10.1038/ncb1236.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCdc42 GTP-Binding ProteinChemotaxisDictyosteliumHumansIntracellular Signaling Peptides and ProteinsLeukocytesMiceModels, BiologicalNeutrophilsPhosphoric Monoester HydrolasesProtein Serine-Threonine KinasesProtein TransportPTEN PhosphohydrolaseRhoA GTP-Binding ProteinRho-Associated KinasesTumor Suppressor ProteinsConceptsRegulation of PTENIntracellular localizationEmbryonic kidney cellsSmall GTPaseDownstream effectorsPhospholipid phosphatase activityRho small GTPasesRegulation of chemotaxisKidney cellsHuman embryonic kidney cellsSmall GTPasesRho familyPhosphoinositide substratesKey residuesActive RhoAPhosphatase activityPTENRhoAGTPaseRegulationHuman tumorsCellsDiverse rangeGTPasesCdc42