2007
Phospholipase C β3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice
Wang Z, Liu B, Wang P, Dong X, Fernandez-Hernando C, Li Z, Hla T, Li Z, Claffey K, Smith JD, Wu D. Phospholipase C β3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. Journal Of Clinical Investigation 2007, 118: 195-204. PMID: 18079968, PMCID: PMC2129238, DOI: 10.1172/jci33139.Peer-Reviewed Original ResearchConceptsPLC-beta3PLC-betaPKC-dependent upregulationMacrophage survivalPLC isoformsNovel roleBcl-xLMultiple inducersSubsequent differentiationApoptotic inductionAtherosclerotic plaquesMacrophage apoptosisApoE-deficient mouse modelPLC activityPLC-beta2Murine macrophagesAtherosclerotic lesion sizeReduction of atherosclerosisPotential targetLipid-laden macrophagesTreatment of atherosclerosisBeta3Key membersMacrophage functionApoptosis
2006
Methods for Studying Neutrophil Chemotaxis
Dong X, Wu D. Methods for Studying Neutrophil Chemotaxis. Methods In Enzymology 2006, 406: 605-613. PMID: 16472691, DOI: 10.1016/s0076-6879(06)06047-2.Peer-Reviewed Original Research