2017
Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation
Goldberg EL, Dixit VD. Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation. Molecular Metabolism 2017, 6: 219-225. PMID: 28180063, PMCID: PMC5279934, DOI: 10.1016/j.molmet.2016.12.008.Peer-Reviewed Original ResearchConceptsNutrient stressFatty acid oxidationAcyl-CoA poolMacrophage energy metabolismAcid oxidationMetabolic stressorsMyeloid lineage cellsStress sensingSwitch mechanismMetabolic homeostasisLineage cellsEnergy metabolismImportant unanswered questionsMuscle cellsHomeostasisCRATHigh-fat diet-induced obesityAcetyltransferase expressionDiet-induced obesityGlucose homeostasisTissue leukocytosisMacrophagesCellsLittermate controlsUnanswered questions
2016
Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence
Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD. Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence. Cell Reports 2016, 14: 1571-1580. PMID: 26876170, PMCID: PMC5992590, DOI: 10.1016/j.celrep.2016.01.044.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutocrine CommunicationBone Marrow CellsCarrier ProteinsGene Expression RegulationHomeostasisImmunity, InnateImmunologic MemoryInflammasomesInterferon-gammaLongevityMacrophagesMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinReceptor, IGF Type 1Receptors, SomatotropinSignal TransductionSpleenT-LymphocytesConceptsNLRP3 inflammasome activationInflammasome activationImmune senescenceAge-related immune senescenceGrowth hormone receptor deficiencyHigher IFNγ secretionNaive T lymphocytesImmune system homeostasisMyeloid lineage cellsEffector memoryIFNγ secretionInflammasome inhibitionEffector cellsChronic inflammationReceptor deficiencyAdvanced ageAge-related activationSystemic activationT lymphocytesGrowth hormone receptorNLRP3 ligandsInnate immuneSomatotropic axisSystem homeostasisNLRP3
2015
Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153)
Goldberg E, Youm Y, Nguyen K, Alnemri E, Dixit V. Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153). The Journal Of Immunology 2015, 194: 48.10-48.10. DOI: 10.4049/jimmunol.194.supp.48.10.Peer-Reviewed Original ResearchBeta-hydroxy butyrateInflammasome activationMyeloid cellsNLRP3-dependent inflammasome activationAnti-inflammatory interventionsNLRP3-dependent ILMyeloid lineage cellsShort-chain fatty acidsDependent inflammasome activationKetone body productionFatty acid oxidationBone lossChronic inflammationAged miceAge-related diseasesNLRP3 inflammasomeSterile inflammationChronic diseasesFunctional declineMetabolic diseasesCognitive declineCalorie restrictionChain fatty acidsInflammationLineage cells