2014
Single- and double-stranded viral RNA generate distinct cytokine and antiviral responses in human fetal membranes
Bakaysa SL, Potter JA, Hoang M, Han CS, Guller S, Norwitz ER, Abrahams VM. Single- and double-stranded viral RNA generate distinct cytokine and antiviral responses in human fetal membranes. Molecular Human Reproduction 2014, 20: 701-708. PMID: 24723465, PMCID: PMC4072183, DOI: 10.1093/molehr/gau028.Peer-Reviewed Original ResearchMeSH KeywordsCytokinesExtraembryonic MembranesFemaleHumansPoly I-CPregnancyRNA, Double-StrandedRNA, ViralUp-RegulationConceptsHuman fetal membranesToll-like receptorsMIP-1βMIP-1αFetal membranesAntiviral responseIL-1βIL-6IL-2Viral infectionG-CSFCytokine/chemokine profilesViral ssRNAAdverse pregnancy outcomesMaternal-fetal interfaceInfection-associated inflammationMCP-1 secretionViral dsRNA analogueTNF-α productionMIP-1α secretionTLR adapter proteinsExpression of IFNβPregnancy outcomesCytokine profileChemokine profiles
2008
Pre‐eclampsia is associated with dendritic cell recruitment into the uterine decidua
Huang S, Chen C, Schatz F, Rahman M, Abrahams V, Lockwood C. Pre‐eclampsia is associated with dendritic cell recruitment into the uterine decidua. The Journal Of Pathology 2008, 214: 328-336. PMID: 18069648, DOI: 10.1002/path.2257.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesCell MovementCells, CulturedChemokinesCulture Media, ConditionedDeciduaDendritic CellsEnzyme-Linked Immunosorbent AssayFemaleGene Expression ProfilingHumansImmunohistochemistryInterleukin-1betaOligonucleotide Array Sequence AnalysisPre-EclampsiaPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdReverse Transcriptase Polymerase Chain ReactionUp-RegulationConceptsFirst trimester decidual cellsDendritic cell infiltrationDendritic cellsDecidual cellsIL-1betaPre-eclampsiaCell infiltrationLeukocyte-free first trimester decidual cellsSpecialized antigen-presenting cellsDecidual dendritic cellsDendritic cell recruitmentPlacental bed biopsiesMature dendritic cellsPro-inflammatory cytokinesAntigen-presenting cellsMarked infiltratesMaternal morbidityPrimiparous patientsSystemic inflammationImmune toleranceSubsequent pregnancyBed biopsiesInflammatory milieuMacrophage infiltrationLeading cause