2024
High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children
Watkins T, Green A, Amat J, Cheemarla N, Hänsel K, Lozano R, Dudgeon S, Germain G, Landry M, Schulz W, Foxman E. High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children. Journal Of Experimental Medicine 2024, 221: e20230911. PMID: 38949638, PMCID: PMC11215523, DOI: 10.1084/jem.20230911.Peer-Reviewed Original ResearchConceptsBacterial pathobiontsRespiratory virusesBurden of virusesSARS-CoV-2Innate immune activationSARS-CoV-2 viral loadDynamic host-pathogen interactionsInnate immune responseViral coinfectionCytokine profileViral loadNasal virusImmune activationProinflammatory responseIL-1BNasopharyngeal samplesHost-pathogen interactionsImmune responseInterferon responsePathobiontsInnate immunityPaired samplesCXCL10Healthy 1-year-oldVirus
2023
Viral Interference During Influenza A–SARS-CoV-2 Coinfection of the Human Airway Epithelium and Reversal by Oseltamivir
Cheemarla N, Watkins T, Mihaylova V, Foxman E. Viral Interference During Influenza A–SARS-CoV-2 Coinfection of the Human Airway Epithelium and Reversal by Oseltamivir. The Journal Of Infectious Diseases 2023, 229: 1430-1434. PMID: 37722683, PMCID: PMC11095529, DOI: 10.1093/infdis/jiad402.Peer-Reviewed Original ResearchSARS-CoV-2 replicationSARS-CoV-2IAV replicationHuman airway epithelial culturesHuman airway epitheliumAirway epithelial culturesHost antiviral responseRobust interferon responseInfluenza infectionRespiratory virusesAirway epitheliumViral infectionAntiviral responseViral interferenceCoinfecting virusSimultaneous infectionHost cell defenseInterferon responseCoinfectionInfectionEpithelial culturesOseltamivirInfluenzaVirusCell defense