2024
Phenotypes of B Cells Producing Autoantibodies in MOGAD Patients (N1.002)
Filipek B, Yandamuri S, Obaid A, Thurman J, Makhani N, Nowak R, Guo Y, Lucchinetti C, Flanagan E, Longbrake E, O’Connor K. Phenotypes of B Cells Producing Autoantibodies in MOGAD Patients (N1.002). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000208259.Peer-Reviewed Original ResearchA Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases.
Yandamuri S, Filipek B, Lele N, Cohen I, Bennett J, Nowak R, Sotirchos E, Longbrake E, Mace E, O'Connor K. A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases. The Journal Of Immunology 2024, 212: 785-800. PMID: 38251887, PMCID: PMC10932911, DOI: 10.4049/jimmunol.2300015.Peer-Reviewed Original ResearchConceptsNeuromyelitis optica spectrum disorderAb-dependent cellular cytotoxicityNK cellsMyasthenia gravisMG patientsInduced Ab-dependent cellular cytotoxicityNK cell-mediated effector functionsPeripheral blood immune cell populationsCell-mediated effector functionsNeuromyelitis optica spectrum disorder patientsBlood immune cell populationsAb-dependent cellular cytotoxicity activityNK marker CD56NK cell markersHLA-DR expressionNK cell subsetsExpression of perforinImmune cell populationsAutoimmune myasthenia gravisElevated disease burdenHLA-DRCell subsetsCellular cytotoxicityChemokine receptorsMultiparameter immunophenotyping
2023
Remission of severe myasthenia gravis after autologous stem cell transplantation
Schlatter M, Yandamuri S, O'Connor K, Nowak R, Pham M, Obaid A, Redman C, Provost M, McSweeney P, Pearlman M, Tees M, Bowen J, Nash R, Georges G. Remission of severe myasthenia gravis after autologous stem cell transplantation. Annals Of Clinical And Translational Neurology 2023, 10: 2105-2113. PMID: 37726935, PMCID: PMC10646993, DOI: 10.1002/acn3.51898.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationRefractory myasthenia gravisAutologous hematopoietic cell transplantationMyasthenia gravisCell transplantationAcetylcholine receptorsAutologous stem cell transplantationPhase 2 clinical trialAmerica (MGFA) clinical classificationMultiple immunomodulatory agentsRabbit antithymocyte globulinSevere myasthenia gravisAutoimmune neurological disordersHigh-dose chemotherapyMyasthenia Gravis FoundationNeuromuscular junction disordersStem cell transplantationTherapeutic plasma exchangeImmune cell subtypesDays of treatmentEffect of treatmentAntithymocyte globulinDisease activityComplete responseUnderwent treatmentMOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity
Yandamuri S, Filipek B, Obaid A, Lele N, Thurman J, Makhani N, Nowak R, Guo Y, Lucchinetti C, Flanagan E, Longbrake E, O'Connor K. MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity. JCI Insight 2023, 8: e165373. PMID: 37097758, PMCID: PMC10393237, DOI: 10.1172/jci.insight.165373.Peer-Reviewed Original ResearchConceptsMyelin oligodendrocyte glycoprotein antibody-associated diseaseAntibody-dependent cellular phagocytosisAntibody-dependent cellular cytotoxicityComplement-dependent cytotoxicityMOG autoantibodiesPatient seraCellular cytotoxicityEffector functionsComplement activityAntibody-associated diseaseMultiple mechanismsNK cellsPatient autoantibodiesCytotoxic capacityLesion histologyCellular phagocytosisFuture relapseIgG subclassesCerebrospinal fluidAutoantibodiesCNS conditionsMOGSerumRelapseCytotoxicity
2021
Lost in post-translational modification-Dengue virus writes its own sequel.
Yandamuri SS, O'Connor KC. Lost in post-translational modification-Dengue virus writes its own sequel. Science Immunology 2021, 6 PMID: 34215681, DOI: 10.1126/sciimmunol.abk1555.Peer-Reviewed Original Research
2020
High-throughput investigation of molecular and cellular biomarkers in NMOSD
Yandamuri SS, Jiang R, Sharma A, Cotzomi E, Zografou C, Ma AK, Alvey JS, Cook LJ, Smith TJ, Yeaman MR, O'Connor KC. High-throughput investigation of molecular and cellular biomarkers in NMOSD. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e852. PMID: 32753407, PMCID: PMC7413712, DOI: 10.1212/nxi.0000000000000852.Peer-Reviewed Original ResearchConceptsNeuromyelitis optica spectrum disorderPeripheral blood mononuclear cellsHealthy controlsNK cellsCell subsetsT cellsUnstimulated peripheral blood mononuclear cellsB-cell activating factorDendritic cell subsetsOptica spectrum disorderRegulatory T cellsNatural killer cellsImmune cell subsetsMultivariable logistic regressionBlood mononuclear cellsSerum analyte levelsMultivariable linear regressionMultivariable regression modelsNovel biomarker candidatesCX3CL1 levelsNMOSD cohortSerum cytokinesDisease relapseKiller cellsSerum cohort
2019
The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL. The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling. ELife 2019, 8: e47117. PMID: 31309928, PMCID: PMC6634972, DOI: 10.7554/elife.47117.Peer-Reviewed Original ResearchConceptsToll-like receptorsCentral nervous systemNeurologic damageMicroglia functionDisruption of TLR4Viral-specific immunityEntire central nervous systemCNS damageMicroglia depletionHomeostatic activationNeurotropic virusesOral administrationClinical diseaseViral infectionGermfree miceNervous systemHost defenseViral replicationMicrogliaTLR4InfectionMicrobiotaAnimalsDamageDemyelinationBiomechanical analysis of motion following sacroiliac joint fusion using lateral sacroiliac screws with or without lumbosacral instrumented fusion
Dall BE, Eden SV, Cho W, Karkenny A, Brooks DM, Hayward GM, Moldavsky M, Yandamuri S, Bucklen BS. Biomechanical analysis of motion following sacroiliac joint fusion using lateral sacroiliac screws with or without lumbosacral instrumented fusion. Clinical Biomechanics 2019, 68: 182-189. PMID: 31234032, DOI: 10.1016/j.clinbiomech.2019.05.025.Peer-Reviewed Original ResearchConceptsSacroiliac joint screwLumbosacral instrumented fusionSacroiliac joint fusionRange of motionJoint rangeSacroiliac screwsInstrumented fusionSacroiliac jointJoint fusionLumbosacral fixationL5-S1 fixationLoad controlSacroiliac joint motionScrew configurationSacroiliac joint injuriesSource of painIntact motionSix-degreeJoint screwsMotion reductionIntact jointLigament injuryJoint hypermobilityJoint injuryFreedom machine
2018
Does pedicle screw fixation of the subaxial cervical spine provide adequate stabilization in a multilevel vertebral body fracture model? An in vitro biomechanical study
Duff J, Hussain MM, Klocke N, Harris JA, Yandamuri SS, Bobinski L, Daniel RT, Bucklen BS. Does pedicle screw fixation of the subaxial cervical spine provide adequate stabilization in a multilevel vertebral body fracture model? An in vitro biomechanical study. Clinical Biomechanics 2018, 53: 72-78. PMID: 29455101, DOI: 10.1016/j.clinbiomech.2018.02.009.Peer-Reviewed Original ResearchConceptsVertebral body fracturesCervical pedicle screwsPedicle screw reconstructionBody fracturesFlexion-extension testingCervical pedicleCervical vertebral body fracturesPedicle screwsBiomechanical studyAnterior-posterior approachSubaxial cervical spineRange of motionGreater initial stabilityLateral mass screwsLateral bendingAxial rotationCervical spineCircumferential fixationGroup 2Group 1Cadaveric specimensC2-T1PedicleAdequate stabilization
2017
Biomechanical Assessment of Stabilization of Simulated Type II Odontoid Fracture with Case Study
Daniel RT, Hussain MM, Klocke N, Yandamuri SS, Bobinski L, Duff JM, Bucklen BS. Biomechanical Assessment of Stabilization of Simulated Type II Odontoid Fracture with Case Study. Asian Spine Journal 2017, 11: 15-23. PMID: 28243364, PMCID: PMC5326723, DOI: 10.4184/asj.2017.11.1.15.Peer-Reviewed Original ResearchType II odontoid fracturesType II dens fracturesDens fracturesPosterior instrumentationOdontoid fracturesFixation techniquesLateral bendingCommon traumatic injuriesCurrent fixation techniquesSurgical fixation techniquesRange of motionBetter fusion outcomesC1-C2Posterior fixation techniquesIntact motionMultiple ligamentSix-degreeFemale patientsSolid fusionRotary motionAtlantoaxial jointFreedom spine simulatorTraumatic injuryChronic instabilityHead turning
2016
Imaging Axonal Degeneration and Repair in Preclinical Animal Models of Multiple Sclerosis
Yandamuri SS, Lane TE. Imaging Axonal Degeneration and Repair in Preclinical Animal Models of Multiple Sclerosis. Frontiers In Immunology 2016, 7: 189. PMID: 27242796, PMCID: PMC4871863, DOI: 10.3389/fimmu.2016.00189.Peer-Reviewed Original ResearchMultiple sclerosisAxonal degenerationCentral nervous system diseaseReduction of neuroinflammationWhite matter damageNervous system diseasesPreclinical mouse modelsNovel therapeutic targetPreclinical animal modelsChronic neuroinflammationMS therapyAxonal damageSymptom reliefNeuronal excitotoxicityMatter damageAxonal regenerationDisease progressionDisease inductionPreclinical modelsMouse modelSystem diseasesTherapeutic targetAnimal modelsCognitive symptomsMyeloid cells
2009
In vivo evaluation of a neural stem cell-seeded prosthesis
Purcell E, Seymour J, Yandamuri S, Kipke D. In vivo evaluation of a neural stem cell-seeded prosthesis. Journal Of Neural Engineering 2009, 6: 049801. DOI: 10.1088/1741-2552/6/4/049801.Peer-Reviewed Original ResearchIn vivo evaluation of a neural stem cell-seeded prosthesis
Purcell E, Seymour J, Yandamuri S, Kipke D. In vivo evaluation of a neural stem cell-seeded prosthesis. Journal Of Neural Engineering 2009, 6: 026005. PMID: 19287078, PMCID: PMC2930820, DOI: 10.1088/1741-2560/6/2/026005.Peer-Reviewed Original ResearchConceptsNeuronal lossGlial encapsulationNeural stem cellsNeurotrophic factorSensory deficitsGraft cellsNeuronal activityChronic applicationBrain tissueHealing responseSubsequent cell deathDegenerative diseasesSynthetic prosthesesTime pointsProgenitor cellsInitial weeksVivo evaluationReactive tissue responseTissue responseCell deathStem cellsWeeksProsthesisImplantationCells