2023
Novel Approaches for Dynamic Visualization of Adverse Event Data in Oncology Clinical Trials: A Case Study Using Immunotherapy Trial S1400-I (SWOG)
Lee S, Fan W, Wang A, Vaidya R, Redman M, Gettinger S, Bazhenova L, Herbst R, Hershman D, Unger J. Novel Approaches for Dynamic Visualization of Adverse Event Data in Oncology Clinical Trials: A Case Study Using Immunotherapy Trial S1400-I (SWOG). JCO Clinical Cancer Informatics 2023, 7: e2200165. PMID: 37084329, PMCID: PMC10281446, DOI: 10.1200/cci.22.00165.Peer-Reviewed Original ResearchConceptsSystem organ classAdverse event dataRandomized phase III trialPhase III trialsCell lung cancerOncology clinical trialsOverall toxicity profileIII trialsNeurologic toxicityTreatment armsCardiac toxicityLung cancerClinical trialsGrade 3High prevalenceOrgan classToxicity profileNivolumabTreatment groupsStage IVEndocrine toxicityType of AEToxicity typesAE termsIpilimumab
2015
Targeted Therapy in Solid Tumors: Lung Cancer
Waqar S, Morgensztern D, Herbst R. Targeted Therapy in Solid Tumors: Lung Cancer. 2015, 224-230. DOI: 10.1002/9781118468678.ch23.Peer-Reviewed Original ResearchNon-small cell lung cancerLung cancerManagement of NSCLCMetastatic non-small cell lung cancerChoice of regimensUnprecedented response ratesProgression-free survivalEarly-stage diseaseIncurable metastatic diseaseCell lung cancerImproved cure ratesToxic treatment optionsMetastatic diseaseStage diseaseCure rateTreatment optionsTargeted therapyToxicity profileSecondary resistanceResponse rateSolid tumorsPatientsTumor progressionTherapyTumors
2007
Toxicity and survival by sex in patients with advanced non-small cell lung carcinoma (NSCLC) on modern Southwest Oncology Group (SWOG) trials
Albain K, Unger J, Gotay C, Davies A, Edelman M, Herbst R, Kelly K, Williamson S, Wozniak A, Gandara D. Toxicity and survival by sex in patients with advanced non-small cell lung carcinoma (NSCLC) on modern Southwest Oncology Group (SWOG) trials. Journal Of Clinical Oncology 2007, 25: 7549-7549. DOI: 10.1200/jco.2007.25.18_suppl.7549.Peer-Reviewed Original ResearchNon-small cell lung carcinomaAdvanced non-small cell lung carcinomaModern chemotherapy eraAge 60Chemotherapy eraPrognostic factorsEstrogen levelsToxicity profileBetter survivalSouthwest Oncology Group trialKaplan-Meier survival estimatesMaximum toxicity gradePatients age 60Cox multivariate modelRisk of deathCell lung carcinomaNumber of toxicitiesWomen age 60Clinical trial literatureSex-related changesEligible patientsNSCLC trialsSurvival benefitChemotherapy prescriptionsRecent trials
2005
Phase I/IIa Study of Cetuximab With Gemcitabine Plus Carboplatin in Patients With Chemotherapy-Naïve Advanced Non–Small-Cell Lung Cancer
Robert F, Blumenschein G, Herbst RS, Fossella FV, Tseng J, Saleh MN, Needle M. Phase I/IIa Study of Cetuximab With Gemcitabine Plus Carboplatin in Patients With Chemotherapy-Naïve Advanced Non–Small-Cell Lung Cancer. Journal Of Clinical Oncology 2005, 23: 9089-9096. PMID: 16301597, DOI: 10.1200/jco.2004.00.1438.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Non-Small-Cell LungCetuximabDeoxycytidineDisease ProgressionDrug Administration ScheduleDrug EruptionsFemaleGemcitabineHumansInfusions, IntravenousLung NeoplasmsMaleMiddle AgedSurvival AnalysisTreatment OutcomeConceptsPhase I/IIa studyAdverse eventsIIa studyOverall survivalLung cancerToxicity profileResponse rateGrade 3 adverse eventsGrade 3 allergic reactionSmall cell lung cancerAcne-like rashMucositis/stomatitisCycles of therapyMedian overall survivalNausea/vomitingSafety/toxicity profileTumor response rateAcceptable toxicity profileFever/chillsCombination of cetuximabCell lung cancerAssessable patientsChemotherapy-naïveStable diseaseMedian survival
2004
Pemetrexed in advanced NSCLC: a review of the clinical data.
Zinner RG, Fossella FV, Herbst RS. Pemetrexed in advanced NSCLC: a review of the clinical data. Oncology 2004, 18: 54-62. PMID: 15339061.Peer-Reviewed Original ResearchConceptsAdvanced NSCLCConcurrent chest radiationPhase II studySecond-line therapyPhase III trialsCell lung cancerFavorable toxicity profileTreatment of mesotheliomaChest radiationII studyIII trialsSystemic dosesThoracic malignanciesFrontline settingLung cancerClinical dataToxicity profilePlatinum agentsSide effectsUS FoodDrug AdministrationPhase IPemetrexedNSCLCNovel mechanismPemetrexed in the Treatment of Advanced Non–Small-Cell Lung Cancer: A Review of the Clinical Data
Zinner RG, Herbst RS. Pemetrexed in the Treatment of Advanced Non–Small-Cell Lung Cancer: A Review of the Clinical Data. Clinical Lung Cancer 2004, 5: s67-s74. PMID: 15117428, DOI: 10.3816/clc.2004.s.006.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerSecond-line activityPhase III trialsIII trialsLung cancerAdvanced non-small cell lung cancerPhase II studyFirst-line therapyCell lung cancerFavorable toxicity profileChest radiationII studyThoracic malignanciesClinical dataSignificant efficacyToxicity profileSide effectsUseful agentFDA approvalPemetrexedPhase ICisplatinTrialsFurther studiesMesothelioma
2003
The rationale and potential of combining novel biologic therapies with radiotherapy: focus on non-small cell lung cancer
Herbst RS, O’Reilly M. The rationale and potential of combining novel biologic therapies with radiotherapy: focus on non-small cell lung cancer. Seminars In Oncology 2003, 30: 113-123. PMID: 12908142, DOI: 10.1016/s0093-7754(03)00269-0.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCell lung cancerLung cancerAnti-epidermal growth factor receptor agentsNovel biologic therapiesEarly clinical investigationConventional cytotoxic agentsNovel combination therapiesTreatment of malignanciesAnti-angiogenic agentsPresent preclinical dataBiologic therapyOngoing trialsCombination therapyPreclinical dataReceptor agentsToxicity profileClinical investigationClinical developmentConventional modalitiesCytotoxic agentsRadiotherapyTherapyCancerHuman cancers