2021
Role of MIF in coordinated expression of hepatic chemokines in patients with alcohol-associated hepatitis
Poulsen KL, Fan X, Kibler CD, Huang E, Wu X, McMullen MR, Leng L, Bucala R, Ventura-Cots M, Argemi J, Bataller R, Nagy LE. Role of MIF in coordinated expression of hepatic chemokines in patients with alcohol-associated hepatitis. JCI Insight 2021, 6: e141420. PMID: 33945507, PMCID: PMC8262327, DOI: 10.1172/jci.insight.141420.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorAlcohol-associated hepatitisChemokine expressionHealthy controlsLiver diseaseRole of MIFMIF KO miceChronic liver diseaseCytokines/chemokinesMigration inhibitory factorUpstream regulatorChemokine signatureChemokine CCL20WT miceCultured hepatocytesMultiple chemokinesChemokine systemInflammatory responseChemokine membersNovel therapiesEthanol feedingPatientsChemokine familyChemokinesInhibitory factorUnexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations
Heinrichs D, Brandt EF, Fischer P, Köhncke J, Wirtz TH, Guldiken N, Djudjaj S, Boor P, Kroy D, Weiskirchen R, Bucala R, Wasmuth HE, Strnad P, Trautwein C, Bernhagen J, Berres ML. Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations. Cells 2021, 10: 252. PMID: 33525493, PMCID: PMC7918903, DOI: 10.3390/cells10020252.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCell PolarityDietDisease ProgressionFibrosisGene Expression RegulationHepatic Stellate CellsHepatocytesHumansLiverMacrophage Migration-Inhibitory FactorsMaleMice, Inbred C57BLModels, BiologicalNatural Killer T-CellsNon-alcoholic Fatty Liver DiseaseReceptors, ImmunologicConceptsMacrophage migration inhibitory factorNon-alcoholic fatty liver diseaseNAFLD progressionLiver fibrogenesisNKT cell populationNKT cell subpopulationsChronic liver injuryFatty liver diseaseNon-alcoholic steatohepatitisAnti-fibrotic propertiesPro-fibrotic effectsMigration inhibitory factorPleiotropic inflammatory cytokineLiver injury modelPro-fibrotic phenotypeMIF expressionMurine resultsNASH patientsNKT cellsLiver injuryLiver diseaseFibrosis markersInflammatory cytokinesDiet feedingInjury model
2000
The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle
Benigni F, Atsumi T, Calandra T, Metz C, Echtenacher B, Peng T, Bucala R. The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. Journal Of Clinical Investigation 2000, 106: 1291-1300. PMID: 11086030, PMCID: PMC381433, DOI: 10.1172/jci9900.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell MovementFructosediphosphatesGlucoseGlycolysisHumansLactic AcidLiverMacrophage Migration-Inhibitory FactorsMacrophagesMiceMusclesPhosphofructokinase-2Phosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)RatsTumor Cells, CulturedTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorMigration inhibitory factorTNF-alphaInhibitory factorTNF-alpha knockout miceMediator macrophage migration inhibitory factorAddition of MIFSystemic inflammatory responseSevere metabolic derangementProinflammatory cytokine productionSerum glucose levelsImmune cell activationAnterior pituitary glandPositive allosteric regulatorMetabolic derangementsAutocrine stimuliCytokine productionGlucose disposalImmune cellsSevere infectionsCatabolic effectsInflammatory responseGlucose levelsInsulin releaseCatabolic responseMacrophage Migration Inhibitory Factor Release by Macrophages after Ingestion of Plasmodium chabaudi-Infected Erythrocytes: Possible Role in the Pathogenesis of Malarial Anemia
Martiney J, Sherry B, Metz C, Espinoza M, Ferrer A, Calandra T, Broxmeyer H, Bucala R. Macrophage Migration Inhibitory Factor Release by Macrophages after Ingestion of Plasmodium chabaudi-Infected Erythrocytes: Possible Role in the Pathogenesis of Malarial Anemia. Infection And Immunity 2000, 68: 2259-2267. PMID: 10722628, PMCID: PMC97412, DOI: 10.1128/iai.68.4.2259-2267.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaAnimalsBone MarrowCells, CulturedDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayErythrocytesErythroid Precursor CellsErythropoiesisErythropoietinFemaleImmunohistochemistryLeukopoiesisLiverMacrophage Migration-Inhibitory FactorsMacrophagesMalariaMiceMice, Inbred BALB CMice, Inbred C3HPlasmodium chabaudiSpleenTime FactorsConceptsMacrophage migration inhibitory factorChabaudi-infected erythrocytesMalarial anemiaP. chabaudi-infected miceBALB/c miceP. chabaudi-infected erythrocytesTumor necrosis factor alphaMacrophage migration inhibitory factor releaseHuman falciparum malariaRed blood cell destructionPlasmodium falciparum infectionMigration inhibitory factorNecrosis factor alphaSuppression of erythropoiesisAntibody neutralization studiesBlood cell destructionHost-derived factorsPlasmodium chabaudi-infected erythrocytesErythropoiesis inhibitorMalaria anemiaActive diseaseCerebral malariaChabaudi infectionFalciparum malariaFalciparum infection