2005
Advanced Glycosylation of LDL: Role in Oxidative Modification and Diabetic Complications
Bucala R, Makita Z, Cerami A, Vlassara H, Koschinsky T. Advanced Glycosylation of LDL: Role in Oxidative Modification and Diabetic Complications. 2005, 286-291. DOI: 10.1533/9781845698393.4.286.Peer-Reviewed Original ResearchTransition metal ionsAmine-containing phospholipidsRedox reactionsMetal ionsFree metalFacile mechanismOxidative modificationOxidationLipid oxidationApoprotein componentsMoietyGlycosylationAcid oxidationIonsAbsorbanceReactionModificationMetalsAGE moietiesFluorescencePhospholipidsPropertiesAdvanced glycosylationImmunochemical propertiesFormation
1996
Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗)
Al-Abed Y, Bucala R, Liebich H, Voelter W. Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗). Journal Of Biological Chemistry 1996, 271: 2892-2896. PMID: 8621676, DOI: 10.1074/jbc.271.6.2892.Peer-Reviewed Original ResearchConceptsChemical ionization mass spectroscopyGas chromatography-mass spectrometry analysisIonization mass spectroscopyChromatography-mass spectrometry analysisOxidation product 4Acid side chainsUnsaturated fatty acyl groupsTransition metalsFatty acid side chainsHead groupsMass spectroscopySide chainsProduct 4Chemical basisCovalent additionFatty acyl groupsFree radical generating systemOxidationRadical generating systemSpectrometry analysisAcyl groupsMajor compoundsTissue LDL receptorsHigh affinityOxidative modification