2023
Urothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain
Ye S, Mahmood D, Ma F, Leng L, Bucala R, Vera P. Urothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain. Cells 2023, 12: 1440. PMID: 37408274, PMCID: PMC10217556, DOI: 10.3390/cells12101440.Peer-Reviewed Original ResearchConceptsHigh mobility group box 1Macrophage migration inhibitory factorBladder painOxidative stressDisulfide HMGB1Mobility group box 1MIF-deficient miceNovel potential therapeutic strategyMigration inhibitory factorGroup box 1Potential therapeutic strategyOxidative stress productionN-acetylcysteine amideERK activationIntravesical treatmentMicturition volumeMicturition parametersReceptor 4Mechanical thresholdPainTherapeutic strategiesBox 1Bladder tissueInhibitory factorWestern blot
2022
Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice
Ye S, Ma F, Mahmood DFD, Meyer-Siegler KL, Leng L, Bucala R, Vera PL. Bladder Oxidative Stress and HMGB1 Release Contribute to PAR4-Mediated Bladder Pain in Mice. Frontiers In Systems Neuroscience 2022, 16: 882493. PMID: 35645739, PMCID: PMC9135998, DOI: 10.3389/fnsys.2022.882493.Peer-Reviewed Original ResearchHigh mobility group box 1Macrophage migration inhibitory factorBladder painIntravesical fluidOxidative stressLevels of HMGB1Mobility group box 1Bladder oxidative stressFemale C57BL/6 miceMigration inhibitory factorGroup box 1Possible therapeutic strategiesN-acetylcysteine amideBladder edemaMIF antagonismMIF deficiencyHMGB1 concentrationsMicturition frequencyMicturition volumeMIF releaseHMGB1 levelsC57BL/6 miceMicturition parametersHistological signsHistological evidence