1999
Sustained Mitogen-activated Protein Kinase (MAPK) and Cytoplasmic Phospholipase A2 Activation by Macrophage Migration Inhibitory Factor (MIF) REGULATORY ROLE IN CELL PROLIFERATION AND GLUCOCORTICOID ACTION*
Mitchell R, Metz C, Peng T, Bucala R. Sustained Mitogen-activated Protein Kinase (MAPK) and Cytoplasmic Phospholipase A2 Activation by Macrophage Migration Inhibitory Factor (MIF) REGULATORY ROLE IN CELL PROLIFERATION AND GLUCOCORTICOID ACTION*. Journal Of Biological Chemistry 1999, 274: 18100-18106. PMID: 10364264, DOI: 10.1074/jbc.274.25.18100.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorPhospholipase A2 activityGlucocorticoid actionRole of MIFRecombinant macrophage migration inhibitory factorMitogen-activated protein kinaseImportant pro-inflammatory mediatorsA2 activityCytosolic phospholipase A2 activityPro-inflammatory mediatorsMigration inhibitory factorPro-inflammatory stimuliImmune cell activationCytoplasmic phospholipase A2Phospholipase A2 activationArachidonic acid releaseGlucocorticoid suppressionERK-dependent pathwayMIF actionInflammatory propertiesInflammatory responseExtracellular signal-regulated mitogen-activated protein kinaseCell activationInhibitory factorA2 activation
1997
Role of Macrophage Migration Inhibitory Factor in the Regulation of the Immune Response
Metz C, Bucala R. Role of Macrophage Migration Inhibitory Factor in the Regulation of the Immune Response. Advances In Immunology 1997, 66: 197-223. PMID: 9328642, DOI: 10.1016/s0065-2776(08)60598-2.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorT cellsImmune responseInhibitory factorAnti-inflammatory effectsInflammatory disease statesAnterior pituitary glandSeptic shockMIF actionMIF proteinInflammatory responseGlucocorticoid actionImmune systemPituitary glandCorticotrophic cellsGlucocorticoidsInhibitory effectDisease statesBaseline statePotential roleMacrophagesCellsResponseArthritis