Glucocorticoid-lens protein adducts in experimentally induced steroid cataracts
Bucala R, Callati M, Manabe S, Cotlier E, Cerami A. Glucocorticoid-lens protein adducts in experimentally induced steroid cataracts. Experimental Eye Research 1985, 40: 853-863. PMID: 4018168, DOI: 10.1016/0014-4835(85)90130-7.Peer-Reviewed Original ResearchNonenzymatic modification of lens crystallins by prednisolone induces sulfhydryl oxidation and aggregate formation: In vitro and in vivo studies
Bucala R, Manabe S, Urban R, Cerami A. Nonenzymatic modification of lens crystallins by prednisolone induces sulfhydryl oxidation and aggregate formation: In vitro and in vivo studies. Experimental Eye Research 1985, 41: 353-363. PMID: 4065253, DOI: 10.1016/s0014-4835(85)80026-9.Peer-Reviewed Original ResearchConceptsSteroid-induced cataractPossible pharmacological strategiesSteroid therapyLens crystallinsPharmacological strategiesLens opacitiesNonenzymatic modificationGlucocorticoid prednisoloneToxic manifestationsTherapeutic levelsPrednisoloneCataractogenic effectVivo studiesGlucocorticoidsCataractLens proteinsSulfhydryl oxidationGel filtration chromatographyPrevious studiesAddition of dithiothreitol