A microbiota derived metabolite and pediatric celiac disease pathogenesis
Kelley K, Girdhar K, Dogru Y, Yang Y, Tolstikov V, Kiebish M, Palm N, Ludvigsson J, Soto G, Zhang M, Altindis E. A microbiota derived metabolite and pediatric celiac disease pathogenesis. The Journal Of Immunology 2024, 212: 0798_4966-0798_4966. DOI: 10.4049/jimmunol.212.supp.0798.4966.Peer-Reviewed Original ResearchCD progressorsCeliac diseaseLamina propriaVillous atrophyTaurodeoxycholic acidOverexpress IL-15HLA-DQ8 moleculesIncreased IgA responsesNatural killer cellsHLA-DQ8 allelesProspective cohort studyPathogenesis of CDC57BL/B6 micePlasma metabolomeCD4+T cellsKiller cellsT cellsCeliac disease pathogenesisIL-15Autoimmune conditionsHLA-DQ8HLA-DQ2Intraepithelial lymphocytesVilli/crypt ratioCohort study