2024
Tertiary Lymphoid Structures and Immunotherapy: Challenges and Opportunities
Ruddle N. Tertiary Lymphoid Structures and Immunotherapy: Challenges and Opportunities. Methods In Molecular Biology 2024, 2864: 299-312. PMID: 39527229, DOI: 10.1007/978-1-0716-4184-2_16.Peer-Reviewed Original ResearchConceptsImmune-related adverse eventsImmune checkpoint inhibitorsTertiary lymphoid structuresSecondary lymphoid organsTA-TLSSusceptibility to immune-related adverse eventsAssociated with favorable clinical outcomesPositive response to immunotherapyResponse to immunotherapyFavorable clinical outcomesCellular compositionVascular growth factorsAccumulation of lymphoid cellsCheckpoint inhibitorsLymphoid neogenesisLymphoid structuresProcess of lymphoid neogenesisClinical outcomesAdenovirus vectorLymphoid cellsTumor-associatedAdverse eventsTumor environmentOrgan rejectionChronic inflammation
2023
Posttransplant Tertiary Lymphoid Organs
Ruddle N. Posttransplant Tertiary Lymphoid Organs. Transplantation 2023, 108: 1090-1099. PMID: 37917987, PMCID: PMC11042531, DOI: 10.1097/tp.0000000000004812.Peer-Reviewed Original ResearchTertiary lymphoid organsOrgan rejectionLymphoid organsCase of immunosuppressionEctopic lymphoid structuresDevelopment of lymphomaLymphoid neogenesisLymph nodesIschemic reperfusionChronic inflammationLymphoid structuresNephrotoxic agentsTumor antigensVascular componentLymphoid cellsTherapeutic manipulationSustained exposureMicrobial infectionsCellular compositionStaging schemeCancerOrgansRejectionImmunosuppressionReperfusionRegulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer
Ruddle N. Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer. Current Opinion In Physiology 2023, 36: 100705. PMID: 38523879, PMCID: PMC10956444, DOI: 10.1016/j.cophys.2023.100705.Peer-Reviewed Original ResearchHigh endothelial venulesTertiary lymphoid structuresLymphoid organsEndothelial venulesImmune checkpoint blockadeFavorable clinical outcomeAdhesion molecule-1Peripheral node addressinAutoimmune lesionsCheckpoint blockadeClinical outcomesEffector cellsChronic inflammationLymphoid structuresAcute inflammationLymphoid cellsMolecule-1InflammationCentral memoryAdhesion moleculesBlood vesselsPrecursor cellsImmunotherapyVenulesOrgans
2019
Organization and Cells of the Immune System
Kavathas P, Krause P, Ruddle N. Organization and Cells of the Immune System. 2019, 21-38. DOI: 10.1007/978-3-030-25553-4_2.ChaptersImmune cellsImmune systemLymphoid organsDifferent immune cell typesTertiary lymphoid organsInnate lymphoid cellsDifferent immune cellsSecondary lymphoid organsImmune cell typesLymphatic vesselsAdaptive immune systemHuman immune systemDendritic cellsBarrier immunityChronic inflammationUrinary tractSoluble mediatorsLymphoid cellsB cellsLymphoid systemMucosal surfacesChemokinesCytokinesOrgansCell types
2014
Lymphatic vessels and tertiary lymphoid organs
Ruddle NH. Lymphatic vessels and tertiary lymphoid organs. Journal Of Clinical Investigation 2014, 124: 953-959. PMID: 24590281, PMCID: PMC3934190, DOI: 10.1172/jci71611.Peer-Reviewed Original Research
1972
Approaches to the Quantitative Analysis of Delayed Hypersensitivity
Ruddle N. Approaches to the Quantitative Analysis of Delayed Hypersensitivity. Current Topics In Microbiology And Immunology 1972, 57: 75-110. PMID: 4554356, DOI: 10.1007/978-3-642-65297-4_3.Peer-Reviewed Original Research