2018
Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus
Greiling TM, Dehner C, Chen X, Hughes K, Iñiguez AJ, Boccitto M, Ruiz DZ, Renfroe SC, Vieira SM, Ruff WE, Sim S, Kriegel C, Glanternik J, Chen X, Girardi M, Degnan P, Costenbader KH, Goodman AL, Wolin SL, Kriegel MA. Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus. Science Translational Medicine 2018, 10 PMID: 29593104, PMCID: PMC5918293, DOI: 10.1126/scitranslmed.aan2306.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensAutoimmunityCell ProliferationFemaleHumansLupus NephritisMaleMiceRibonucleoproteinsT-LymphocytesConceptsLupus patientsGlomerular immune complex depositsPositive lupus patientsImmune complex depositsGerm-free miceSigns of autoimmunityB cell responsesT cell clonesNovel treatment approachesTriggers of autoimmunityCommensal bacterial speciesEarliest autoantibodiesChronic autoimmunityAutoimmune diseasesHealthy controlsT cellsTreatment approachesSusceptible individualsAutoimmunityCell responsesCommensal speciesLupusPatientsCell clonesGut commensals
2015
Langerhans Cells Facilitate UVB-Induced Epidermal Carcinogenesis
Lewis JM, Bürgler CD, Freudzon M, Golubets K, Gibson JF, Filler RB, Girardi M. Langerhans Cells Facilitate UVB-Induced Epidermal Carcinogenesis. Journal Of Investigative Dermatology 2015, 135: 2824-2833. PMID: 26053049, PMCID: PMC4640962, DOI: 10.1038/jid.2015.207.Peer-Reviewed Original ResearchConceptsLangerhans cellsGroup 3 innate lymphoid cellsAbsence of LCsRole of LCsSquamous cell carcinoma formationInnate lymphoid cellsUVB-induced carcinogenesisInnate immune cellsAcute UVB exposureT-cell independentTumor suppressor gene p53IL-22Cutaneous carcinogenesisImmune cellsTumor outgrowthKC populationLymphoid cellsChronic exposureKC proliferationUVB exposureCarcinoma formationClonal expansionEpidermal carcinogenesisGene p53Carcinogenesis
2011
Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature
Morcos SM, Girardi M, Subtil A, Wilson LD, Cowper SE. Mycosis fungoides exhibiting features of a dermatofibroma: a case report and review of the literature. Journal Of Cutaneous Pathology 2011, 39: 40-46. PMID: 22059953, DOI: 10.1111/j.1600-0560.2011.01804.x.Peer-Reviewed Case Reports and Technical NotesConceptsMycosis fungoidesLesions of MFStage IA mycosis fungoidesUnusual clinical presentationLarge cell transformationClinical cluesClinical presentationDermal lymphocytesPatient populationFibrohistiocytic proliferationCase reportClinical managementAtypical lesionsRight forearmSuspicious tumorsBenign lesionsLesionsFungoidesDermatofibromaPatientsPrognosisLymphocytesTumorsIntraepidermalPlaques
2005
Cross-Comparison of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis
Girardi M, Duncan KO, Tigelaar RE, Imaeda S, Watsky KL, McNiff JM. Cross-Comparison of Patch Test and Lymphocyte Proliferation Responses in Patients With a History of Acute Generalized Exanthematous Pustulosis. American Journal Of Dermatopathology 2005, 27: 343-346. PMID: 16121058, DOI: 10.1097/01.dad.0000160982.75176.6c.Peer-Reviewed Original ResearchConceptsAcute generalized exanthematous pustulosisPatch test resultsPositive patch test resultsGeneralized exanthematous pustulosisLymphocyte proliferative responsesProliferative responseExanthematous pustulosisPeripheral T-cell proliferative responsesT cell-mediated immune responsesDrug-specific T cellsVitro lymphocyte proliferative responseCalcium channel blocker diltiazemCell-mediated immune responsesDelayed-type hypersensitivity reactionT cell proliferative responsesAdverse cutaneous reactionsLymphocyte proliferation responseChannel blocker diltiazemCell proliferative responsesPatch test sitesNeutrophilic pustulesClinical responsePerivascular lymphocytesCutaneous reactionsHypersensitivity reactions