2021
Chronic UV radiation–induced RORγt+ IL-22–producing lymphoid cells are associated with mutant KC clonal expansion
Lewis JM, Monico PF, Mirza FN, Xu S, Yumeen S, Turban JL, Galan A, Girardi M. Chronic UV radiation–induced RORγt+ IL-22–producing lymphoid cells are associated with mutant KC clonal expansion. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2016963118. PMID: 34504008, PMCID: PMC8449378, DOI: 10.1073/pnas.2016963118.Peer-Reviewed Original ResearchConceptsChronic UV exposureLangerhans cellsIL-22Cutaneous carcinogenesisCutaneous squamous cell carcinoma (cSCC) developmentChronic ultraviolet radiation exposureSquamous cell carcinoma developmentClonal expansionEpidermal Langerhans cellsToll-like receptorsSkin cancer preventionGreatest risk factorDouble-deficient miceUltraviolet radiation exposureKey immune componentsImmune shiftKC growthIL-17ARisk factorsCancer preventionT cellsImmune responseCarcinoma developmentIntracellular CD3Immune components
2020
Cutaneous Photoprotection: A Review of the Current Status and Evolving Strategies.
Suozzi K, Turban J, Girardi M. Cutaneous Photoprotection: A Review of the Current Status and Evolving Strategies. The Yale Journal Of Biology And Medicine 2020, 93: 55-67. PMID: 32226337, PMCID: PMC7087054.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaBasal cell carcinomaCell carcinomaRisk factorsMajor environmental risk factorSquamous cell carcinomaAdditional risk factorsEnvironmental risk factorsDevelopment of melanomaUltraviolet radiation exposureLifestyle modificationTopical therapyImmune statusCutaneous carcinogenesisImmune factorsCell malignant transformationDrug Administration regulationsInsufficient evidenceMultifactorial mechanismsSkin cancerMalignant transformationFavorable aestheticsTumor developmentClonal expansionRadiation exposure
2015
Langerhans Cells Facilitate UVB-Induced Epidermal Carcinogenesis
Lewis JM, Bürgler CD, Freudzon M, Golubets K, Gibson JF, Filler RB, Girardi M. Langerhans Cells Facilitate UVB-Induced Epidermal Carcinogenesis. Journal Of Investigative Dermatology 2015, 135: 2824-2833. PMID: 26053049, PMCID: PMC4640962, DOI: 10.1038/jid.2015.207.Peer-Reviewed Original ResearchConceptsLangerhans cellsGroup 3 innate lymphoid cellsAbsence of LCsRole of LCsSquamous cell carcinoma formationInnate lymphoid cellsUVB-induced carcinogenesisInnate immune cellsAcute UVB exposureT-cell independentTumor suppressor gene p53IL-22Cutaneous carcinogenesisImmune cellsTumor outgrowthKC populationLymphoid cellsChronic exposureKC proliferationUVB exposureCarcinoma formationClonal expansionEpidermal carcinogenesisGene p53Carcinogenesis