Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma
Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD, Chan WC, Zhao T, Haioun C, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Campo E, Montserrat E, Lopez-Guillermo A, Ott G, Muller-Hermelink HK, Connors JM, Braziel R, Grogan TM, Fisher RI, Miller TP, LeBlanc M, Chiorazzi M, Zhao H, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Staudt LM. Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma. Journal Of Experimental Medicine 2003, 198: 851-862. PMID: 12975453, PMCID: PMC2194208, DOI: 10.1084/jem.20031074.Peer-Reviewed Original ResearchMeSH KeywordsAdultChromosomes, Human, Pair 19Diagnosis, DifferentialGene Expression ProfilingHodgkin DiseaseHumansLymphoma, B-CellLymphoma, Large B-Cell, DiffuseMediastinal NeoplasmsMiddle AgedMolecular Diagnostic TechniquesOligonucleotide Array Sequence AnalysisSurvival RateTreatment OutcomeTumor Cells, CulturedConceptsGene expressionHodgkin's lymphoma cellsGenomic lociNeighboring genesMolecular diagnosisPMBL patientsPrimary mediastinal B-cell lymphomaLymphoma cellsHodgkin's lymphoma cell linesLymphoma cell linesDiffuse large B-cell lymphomaDevelopment of therapiesGenesT cell activationPrecise molecular diagnosisCell linesB-cell lymphomaMediastinal B-cell lymphomaLarge B-cell lymphomaCell activationCell lymphomaExpressionHodgkin's lymphomaDLBCL patientsCellsThe proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma
Rosenwald A, Wright G, Wiestner A, Chan C, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003, 3: 185-197. PMID: 12620412, DOI: 10.1016/s1535-6108(03)00028-x.Peer-Reviewed Original ResearchMeSH KeywordsADP-Ribosylation FactorsAdultAgedAged, 80 and overAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCyclin D1Cyclin-Dependent Kinase Inhibitor p16DNA-Binding ProteinsFemaleGene Expression ProfilingGenes, NeoplasmHumansLymphoma, Mantle-CellMaleMiddle AgedNeoplasm ProteinsPrognosisProtein Serine-Threonine KinasesReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, NeoplasmSurvival RateTumor Suppressor Protein p53Tumor Suppressor ProteinsUntranslated RegionsConceptsMantle cell lymphoma