2022
Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation
Gehlhaar A, Inala A, Llivichuzhca-Loja D, Silva TN, Adegboye CY, O’Connell A, Konnikova L. Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation. Journal Of Inflammation Research 2022, 15: 1873-1887. PMID: 35342295, PMCID: PMC8943607, DOI: 10.2147/jir.s288288.Peer-Reviewed Original ResearchT cellsIntestinal inflammationIntestinal inflammatory responseDamaging autoimmune responsesTrillions of microorganismsImmunological balanceAutoimmune responseImmune homeostasisInflammatory responseImmune systemMucosal interfaceBarrier sitesHuman intestineInflammationIntestinePrevious evidenceCellsCD8CD4ThymusResponse
2021
Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia
Konnikova L, Robinson TO, Owings AH, Shirley JF, Davis E, Tang Y, Wall S, Li J, Hasan MH, Gharaibeh RZ, Mendoza Alvarez LB, Ryan LK, Doty A, Chovanec JF, O'Connell MP, Grunes DE, Daley WP, Mayer E, Chang L, Liu J, Snapper SB, Milner JD, Glover SC, Lyons JJ. Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia. Journal Of Allergy And Clinical Immunology 2021, 148: 813-821.e7. PMID: 33865872, PMCID: PMC9017395, DOI: 10.1016/j.jaci.2021.04.004.Peer-Reviewed Original ResearchConceptsClass-switched memory B cellsMemory B cellsB cellsSyndrome cohortCell pyroptosisFunctional GI diseasesQuiescent Crohn's diseaseSmall intestinal immunopathologySubclinical intestinal inflammationFunctional gastrointestinal symptomsMast cell numbersTissue mast cellsExpression of CD203cBasal serum tryptaseElevated basal serum tryptaseIntestinal immunopathologyGastrointestinal symptomsImmunologic findingsIntestinal inflammationCrohn's diseaseHLA-DRSmall bowelGI diseaseIgG reactiveImmunologic characteristics
2018
DOP010 Activating PIK3CD mutations cause severe intestinal lymphonodular hyperplasia and an IBD-like phenotype
Farachi S, Werner L, Konnikova L, Rea F, Vardi I, Romeo E, Barel O, De Angelis P, Dall’Oglio L, Rechavi G, Snapper S, Somech R, Weiss B, Cancrini C, Shouval D. DOP010 Activating PIK3CD mutations cause severe intestinal lymphonodular hyperplasia and an IBD-like phenotype. Journal Of Crohn's And Colitis 2018, 12: s36-s37. DOI: 10.1093/ecco-jcc/jjx180.047.Peer-Reviewed Original ResearchIBD-like phenotypeCD8 T cellsWhole-exome sequencingLymphonodular hyperplasiaPIK3CD mutationsT cellsIntestinal diffuse large B-cell lymphomaDiffuse large B-cell lymphomaExome sequencingLarge B-cell lymphomaIntestinal immune cellsEarly-onset IBDRecurrent sinopulmonary infectionsT-cell lymphopeniaB-cell lymphomaPI3K inhibitorsFirst yearNovel PI3K inhibitorsDifferent monogenic disordersGastrointestinal manifestationsMemory CD4Chronic diarrheaImmunological alterationsIntestinal inflammationIgM levels
2016
Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency
Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB. Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology 2016, 151: 1100-1104. PMID: 27693323, PMCID: PMC5124405, DOI: 10.1053/j.gastro.2016.08.055.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAdultAnimalsAntirheumatic AgentsCaspase 8CD4-Positive T-LymphocytesCells, CulturedChild, PreschoolColitisGene Expression RegulationHomeodomain ProteinsHumansImmunity, InnateInflammasomesInflammatory Bowel DiseasesInterferon-gammaInterleukin 1 Receptor Antagonist ProteinInterleukin-10Interleukin-10 Receptor alpha SubunitInterleukin-17Interleukin-1betaLipopolysaccharidesMacrophagesMiceMice, KnockoutMutationNLR Family, Pyrin Domain-Containing 3 ProteinProtein BiosynthesisReceptors, Interleukin-10Signal TransductionTumor Necrosis Factor-alphaConceptsInflammatory bowel diseaseProduction of IL1βBowel diseaseIntestinal inflammationT cellsAllogeneic hematopoietic stem cell transplantationInterleukin-10 Receptor DeficiencyHematopoietic stem cell transplantationStem cell transplantationInnate immune cellsActivation of CD4IL1 receptor antagonistTumor necrosis factorInterleukin-10 receptorProduction of IL1Stimulation of macrophagesImmune productionSpontaneous colitisReceptor deficiencyCell transplantationHistologic responseImmune cellsInterleukin-1βDeficient miceNecrosis factor