2023
Applications of CRISPR technology in cellular immunotherapy
Zhou X, Renauer P, Zhou L, Fang S, Chen S. Applications of CRISPR technology in cellular immunotherapy. Immunological Reviews 2023, 320: 199-216. PMID: 37449673, PMCID: PMC10787818, DOI: 10.1111/imr.13241.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors
Liu Y, Liu G, Wang J, Zheng ZY, Jia L, Rui W, Huang D, Zhou ZX, Zhou L, Wu X, Lin S, Zhao X, Lin X. Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors. Science Translational Medicine 2021, 13 PMID: 33762437, DOI: 10.1126/scitranslmed.abb5191.Peer-Reviewed Original ResearchConceptsCAR T cellsT cell receptorSolid tumorsChimeric antigen receptor T-cell therapyMultiple solid tumor modelsRefractory solid tumorsT-cell therapyDurable disease controlHigh response rateSynthetic T cell receptorsB-cell malignanciesHigh antigen sensitivitySolid tumor modelsAntigen recognition domainClinical benefitAntigen stimulationTumor relapseLimited efficacyAntigen sensitivityAntitumor effectsCell malignanciesResponse rateNotable toxicityTumor modelDisease control