Plasma cells in muscle in inclusion body myositis and polymyositis
Greenberg S, Bradshaw E, Pinkus J, Pinkus G, Burleson T, Due B, Bregoli L, O’Connor K, Amato A. Plasma cells in muscle in inclusion body myositis and polymyositis. Neurology 2005, 65: 1782-1787. PMID: 16344523, DOI: 10.1212/01.wnl.0000187124.92826.20.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, SurfaceAutoantigensBiomarkersBiopsyB-LymphocytesCell DifferentiationCell LineageHumansImmunoglobulinsImmunohistochemistryLymphocyte ActivationMembrane GlycoproteinsMuscle, SkeletalMyositis, Inclusion BodyPlasma CellsPolymyositisProteoglycansRNA, MessengerSyndecan-1SyndecansT-LymphocytesConceptsInclusion body myositisBody myositisB cellsImmunoglobulin gene transcriptsPlasma cellsImmunohistochemical studyCell-mediated immune mechanismsMore T cellsT cell populationsMuscles of patientsMuscle biopsy specimensPrevious immunohistochemical studiesB cell activationDifferentiated B cellsB-cell lineageCell surface markersImmunoglobulin gene rearrangementsUntreated patientsHumoral mechanismsBiopsy specimensImmune mechanismsLaser capture microdissectionT cellsPolymyositisMyositisCharacterization of in vivo expanded OspA-specific human T-cell clones
Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT, Hafler DA. Characterization of in vivo expanded OspA-specific human T-cell clones. Clinical Immunology 2005, 115: 313-322. PMID: 15893699, DOI: 10.1016/j.clim.2005.02.015.Peer-Reviewed Original ResearchConceptsT cell clonesMajor histocompatibility complex class II tetramersTreatment-resistant Lyme arthritisCD4 T-cell clonesDistinct T-cell clonesT cell receptor repertoireHuman T cell clonesClass II tetramersBeta chainT cell recognitionTCR contact residuesTCR beta chainT cell receptorCell flow cytometryTCR usageImmune compartmentLyme arthritisAutoimmune diseasesMicrobial antigensT cellsOspA epitopeImmunodominant epitopesSynovial fluidReceptor repertoireReactive clones