Restoring immune tolerance in neuromyelitis optica
Bar-Or A, Steinman L, Behne J, Benitez-Ribas D, Chin P, Clare-Salzler M, Healey D, Kim J, Kranz D, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei C, Weiner H, Zamvil S, Smith T, Yeaman M, Aktas O, Amezcua L, Appiwatanakul M, Asgari N, Banwell B, Bennett J, Bowen J, Cabre P, Chitnis T, Cohen J, De Seze J, Fujihara K, Han M, Hellwig K, Hintzen R, Hooper D, Iorio R, Jacob A, Jarius S, Kim H, Kissani N, Klawiter E, Kleiter I, Lana-Peixoto M, Leite M, Levy M, Lublin F, Draayer Y, Marignier R, Matiello M, Nakashima I, O’Connor K, Palace J, Pandit L, Paul F, Prayoonwiwat N, Riley C, Ruprecht K, Saiz A, Siritho S, Tenembaum S, Weinshenker B, Wingerchuk D, Würfel J. Restoring immune tolerance in neuromyelitis optica. Neurology Neuroimmunology & Neuroinflammation 2016, 3: &na;. PMID: 27648464, PMCID: PMC5015540, DOI: 10.1212/nxi.0000000000000277.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNMO/SDImmune toleranceAquaporin-4Neuromyelitis optica spectrum disorderNormal host defense mechanismsOptica spectrum disorderHost defense mechanismsOral tolerizationNeuromyelitis opticaOptic nerveParticular brain regionsAutoimmune diseasesAstrocyte functionSpinal cordClinical variantsNovel therapiesDominant autoantigenClinical developmentPotential cureB cellsBrain regionsExperimental modelDiseaseCharacteristic phenotypeAutoantigensRestoring immune tolerance in neuromyelitis optica
Steinman L, Bar-Or A, Behne J, Benitez-Ribas D, Chin P, Clare-Salzler M, Healey D, Kim J, Kranz D, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei C, Weiner H, Zamvil S, Yeaman M, Smith T, Consortium G, Aktas O, Amezcua L, Appiwatanakul M, Asgari N, Banwell B, Bennett J, Bowen J, Cabre P, Chitnis T, Cohen J, De Seze J, Fujihara K, Han M, Hellwig K, Hintzen R, Hooper D, Iorio R, Jacob A, Jarius S, Kim H, Kissani N, Klawiter E, Kleiter I, Lana-Peixoto M, Leite M, Levy M, Lublin F, Draayer Y, Marignier R, Matiello M, Nakashima I, O’Connor K, Palace J, Pandit L, Paul F, Prayoonwiwat N, Riley C, Ruprecht K, Saiz A, Siritho S, Tenembaum S, Weinshenker B, Wingerchuk D, Würfel J. Restoring immune tolerance in neuromyelitis optica. Neurology Neuroimmunology & Neuroinflammation 2016, 3: &na;. PMID: 27648463, PMCID: PMC5015539, DOI: 10.1212/nxi.0000000000000276.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNMO/SDNeuromyelitis opticaImmune toleranceAquaporin-4 (AQP4) water channel proteinKey immune mechanismsImmune tolerizationDevelopment of cancerEmpirical therapyOptic nerveRandomized trialsImmunologic suppressionAutoimmune diseasesSerious infectionsAstrocyte dysfunctionCurrent therapiesImmune mechanismsSpinal cordClinical variantsDominant autoantigenAquaporin-4Therapeutic restorationRestorative techniquesTherapyOpticaPatients