1994
Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target.
Fatenejad S, Brooks W, Schwartz A, Craft J. Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target. The Journal Of Immunology 1994, 152: 5523-31. PMID: 7514640, DOI: 10.4049/jimmunol.152.11.5523.Peer-Reviewed Original ResearchConceptsMRL/lpr miceMRL/Mp-lpr/lpr miceLpr miceAnti-Sm AbsHuman SLEAnti-Sm responseRibonucleoprotein antibodiesNormal miceImmune responseMiceSLEEarly AbsSimilar epitopesD proteinsSerumHuman serumEpitopesU1 snRNP particleFrequent responsePrevious findingsAbResponseSnRNP particlesHumansPrevious observations
1993
Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.
Fatenejad S, Mamula MJ, Craft J. Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 12010-12014. PMID: 8265662, PMCID: PMC48115, DOI: 10.1073/pnas.90.24.12010.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoreactive T cellsLupus erythematosusT cellsAutoantibody productionSuch miceAutoreactive helper T cellsHelper T-cell determinantsHelper T cellsT cell determinantsAutoantibody responseAutoimmune responseAntibody responseNormal miceImmune responseB cellsAutoantibodiesErythematosusMiceCentral targetPatientsImmunizationSnRNP particlesCellsMolecular mimics