2002
IL-10 Regulates Murine Lupus
Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert ME, McNiff J, Madaio MP, Craft J. IL-10 Regulates Murine Lupus. The Journal Of Immunology 2002, 169: 2148-2155. PMID: 12165544, DOI: 10.4049/jimmunol.169.4.2148.Peer-Reviewed Original ResearchConceptsIL-10Murine lupusHuman systemic lupus erythematosusAnti-dsDNA autoantibody productionSeverity of lupusTh1 cytokine responseAnti-dsDNA autoantibodiesSystemic lupus erythematosusIFN-gamma productionIL-10 locusMRL/MpJPotential therapeutic benefitLupus syndromeSevere glomerulonephritisSevere lupusLupus modelsLupus erythematosusRIL-10Autoantibody productionCytokine responsesHuman lupusSerum concentrationsProtective effectSkin lesionsLittermate controls
1986
Clinical manifestations of lyme disease
Steere A, Bartenhagen N, Craft J, Hutchinson G, Newman J, Pachner A, Rahn D, Sigal L, Taylor E, Malawista S. Clinical manifestations of lyme disease. International Journal Of Medical Microbiology 1986, 263: 201-205. PMID: 3554839, DOI: 10.1016/s0176-6724(86)80123-7.Peer-Reviewed Original ResearchConceptsMigratory musculoskeletal painErythema chronicum migransLyme diseaseMusculoskeletal painClinical manifestationsUnique skin lesionNon-productive coughDifferent clinical manifestationsFrank arthritisMononeuritis multiplexAcute myopericarditisCardiac involvementCranial neuritisSkin involvementUrticarial rashSore throatNeurologic abnormalitiesPeriorbital edemaAV blockDisease onsetSecondary lesionsSkin lesionsPatientsDiseaseLesions
1983
The early clinical manifestations of Lyme disease.
Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE. The early clinical manifestations of Lyme disease. Annals Of Internal Medicine 1983, 99: 76-82. PMID: 6859726, DOI: 10.7326/0003-4819-99-1-76.Peer-Reviewed Original ResearchConceptsLyme diseaseSkin lesionsElevated serum IgM levelsMigratory musculoskeletal painTick-transmitted spirochetesUnique skin lesionAspartate transaminase levelsEarly clinical manifestationsEarly Lyme diseaseSerum IgM levelsErythema chronicum migransMeningeal irritationLaboratory abnormalitiesNonproductive coughTransaminase levelsUrticarial rashMusculoskeletal painRegional lymphadenopathySkin manifestationsSore throatDermatologic manifestationsSerologic testingClinical manifestationsIgM levelsPeriorbital edemaThe Spirochetal Etiology of Lyme Disease
Steere A, Grodzicki R, Kornblatt A, Craft J, Barbour A, Burgdorfer W, Schmid G, Johnson E, Malawista S. The Spirochetal Etiology of Lyme Disease. New England Journal Of Medicine 1983, 308: 733-740. PMID: 6828118, DOI: 10.1056/nejm198303313081301.Peer-Reviewed Original ResearchConceptsLyme diseaseAntibody titersIgM titersSpecific IgM antibody titersSpecific IgG antibody titersElevated IgM titersI. dammini spirocheteIgG antibody titersIgM antibody titersTiters of IgGOnset of diseaseInfectious mononucleosisControl patientsImmunologic featuresIgG titersEarly diseaseControl subjectsSpirochetal etiologySkin lesionsCerebrospinal fluidPatientsLate manifestationSixth weekDiseaseTiters