1986
Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.
Craft JE, Fischer DK, Shimamoto GT, Steere AC. Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. Journal Of Clinical Investigation 1986, 78: 934-939. PMID: 3531237, PMCID: PMC423723, DOI: 10.1172/jci112683.Peer-Reviewed Original ResearchConceptsIgG responsesIgM responseEarly diseaseLyme diseaseImmunoglobulin M responseImmunoglobulin G responseBorrelia burgdorferiSpirochetal antigensG responsesIgG antibodiesProlonged illnessPatientsM responseIllnessDiseaseAntigenB. burgdorferiMonthsLimited responseIgMBurgdorferiSuch responsesResponseArthritisYears
1984
Antibody Response in Lyme Disease: Evaluation of Diagnostic Tests
Craft J, Grodzicki R, Steere A. Antibody Response in Lyme Disease: Evaluation of Diagnostic Tests. The Journal Of Infectious Diseases 1984, 149: 789-795. PMID: 6373966, DOI: 10.1093/infdis/149.5.789.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayAntibody responseLyme diseaseIgM antibodiesAntibody titersSpecific IgM antibody titersDiagnostic testsSpecific IgG antibody titersIgG antibody titersIgM antibody titersSerial serum samplesSpecific IgM antibodiesMonths of remissionCross-reactive antibodiesIxodes dammini spirocheteBetter diagnostic testsTiters of seraEarly diseaseControl subjectsAdsorption of serumPatientsSuch titersHigh titersDiseaseSerum samples
1983
The Spirochetal Etiology of Lyme Disease
Steere A, Grodzicki R, Kornblatt A, Craft J, Barbour A, Burgdorfer W, Schmid G, Johnson E, Malawista S. The Spirochetal Etiology of Lyme Disease. New England Journal Of Medicine 1983, 308: 733-740. PMID: 6828118, DOI: 10.1056/nejm198303313081301.Peer-Reviewed Original ResearchConceptsLyme diseaseAntibody titersIgM titersSpecific IgM antibody titersSpecific IgG antibody titersElevated IgM titersI. dammini spirocheteIgG antibody titersIgM antibody titersTiters of IgGOnset of diseaseInfectious mononucleosisControl patientsImmunologic featuresIgG titersEarly diseaseControl subjectsSpirochetal etiologySkin lesionsCerebrospinal fluidPatientsLate manifestationSixth weekDiseaseTiters