1997
Vascular cells have limited capacities to activate and differentiate T cells: Implications for transplant vascular sclerosis
Pober J, Ma W, Biedermann B, Libby P. Vascular cells have limited capacities to activate and differentiate T cells: Implications for transplant vascular sclerosis. Transplant Immunology 1997, 5: 251-254. PMID: 9504143, DOI: 10.1016/s0966-3274(97)80004-4.Peer-Reviewed Original Research
1996
CAN GRAFT ENDOTHELIAL CELLS INITIATE A HOST ANTI-GRAFT IMMUNE RESPONSE?1
Pober2 3, G. O, L. R, O.S. S. CAN GRAFT ENDOTHELIAL CELLS INITIATE A HOST ANTI-GRAFT IMMUNE RESPONSE?1. Transplantation 1996, 61: 343-349. PMID: 8610337, DOI: 10.1097/00007890-199602150-00001.Commentaries, Editorials and Letters
1995
Human vascular smooth muscle cells poorly co-stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro.
Murray AG, Libby P, Pober JS. Human vascular smooth muscle cells poorly co-stimulate and actively inhibit allogeneic CD4+ T cell proliferation in vitro. The Journal Of Immunology 1995, 154: 151-61. PMID: 7995934, DOI: 10.4049/jimmunol.154.1.151.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsT cell proliferationClass II moleculesHuman vascular smooth muscle cellsMHC class II moleculesT cellsIL-2 productionSmooth muscle cellsEndothelial cellsCell proliferationFunctional MHC class II moleculesII-positive endothelial cellsIL-2-producing cellsMuscle cellsPre-activated T cellsAllogeneic endothelial cellsNitric oxide synthesisInhibition of proliferationVSMC-conditioned mediumAllogeneic CD4CD25 expressionInhibits CD4Immunologic functionVSMC expressionSaphenous vein
1994
Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells.
Epperson DE, Pober JS. Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells. The Journal Of Immunology 1994, 153: 5402-12. PMID: 7989746, DOI: 10.4049/jimmunol.153.12.5402.Peer-Reviewed Original ResearchConceptsCD8 T cellsMemory CD8 T cellsT cell proliferative responsesAllogeneic endothelial cellsCell proliferative responsesT cellsAdhesion molecule-1Endothelial cellsCD8/IL-2Proliferative responseMolecule-1CD4 T cell proliferative responsesLate activation Ag-4Human CD8 T cellsVascular cell adhesion molecule-1Class II MHC expressionIntercellular adhesion molecule-1Cell adhesion molecule-1CD4 T cellsIFN-gamma secretionOrgan graft rejectionIL-2R alpha subunitIntercellular adhesion molecule-2CD8 cells
1991
MS-1 sinusoidal endothelial antigen is expressed by factor XIIIa+, HLA-DR+ dermal perivascular dendritic cells.
Walsh LJ, Goerdt S, Pober JS, Sueki H, Murphy GF. MS-1 sinusoidal endothelial antigen is expressed by factor XIIIa+, HLA-DR+ dermal perivascular dendritic cells. Laboratory Investigation 1991, 65: 732-41. PMID: 1684403.Peer-Reviewed Original ResearchMeSH KeywordsAntigen-Presenting CellsAntigensDendritic CellsEndotheliumHLA-DR AntigensHumansPhenotypeSkinTransglutaminasesConceptsPerivascular dendritic cellsDendritic cellsEndothelial cellsInterstitial cellsDendritic interstitial cellsNormal human skinVascular endothelial cellsNonlymphoid organsEndothelial antigensHLA-DRDermal dendrocytesMast cellsImmunofluorescence labeling techniquePerivascular localizationSinusoidal endotheliumPhagocytic macrophagesPerivascular cellsSinusoidal spacesLymphatic endothelial cellsMonoclonal antibodiesBlood vascular endothelial cellsAntibodiesFactor XIIIaBasement membraneDendritic morphologyImmunologic Interactions of T Lymphocytes with Vascular Endothelium
Pober J, Cotran R. Immunologic Interactions of T Lymphocytes with Vascular Endothelium. Advances In Immunology 1991, 50: 261-302. PMID: 1950797, DOI: 10.1016/s0065-2776(08)60827-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntigen-Presenting CellsCell MovementEndothelium, VascularHLA AntigensHumansLymphocyte ActivationT-LymphocytesConceptsMemory T cellsT cellsVascular endotheliumPrimary antigen-presenting cellsAntigen-presenting functionAntigen-presenting cellsNaive T cellsContext of transplantationEffective T cell activationCultured human endothelial cellsT cell activationVivo immune systemLymph nodesHuman endothelial cellsHypersensitivity reactionsImmunologic interactionsIL-8Preferential homingT lymphocytesInflammatory sitesAntigen specificityImmune systemRejection reactionCell activationMemory responses
1990
The Endothelial Cell as a Regulator of T‐Cell Function
Hughes. C, Savage C, Pober JS. The Endothelial Cell as a Regulator of T‐Cell Function. Immunological Reviews 1990, 117: 85-102. PMID: 2258192, DOI: 10.1111/j.1600-065x.1990.tb00568.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Presenting CellsAntigens, Differentiation, T-LymphocyteEndothelium, VascularHumansMajor Histocompatibility ComplexReceptors, ImmunologicT-LymphocytesConceptsIL-2 productionT cell IL-2 productionT cellsClass II moleculesLFA-3Peripheral blood mononuclear cellsAntigen-presenting capacityMemory T cellsMHC class II moleculesBlood mononuclear cellsNon-immune cell typesT cell functionNon-polymorphic regionsT cell linesCostimulatory cellsMononuclear cellsIL-2Allospecific CTLICAM-1IFN-gammaVCAM-1Immunosuppressive drug CsAAbility of ECCostimulator activityVLA-4The potential roles of vascular endothelium in immune reactions
Pober J, Doukas J, Hughes C, Savage C, Munro J, Cotran R. The potential roles of vascular endothelium in immune reactions. Human Immunology 1990, 28: 258-262. PMID: 2190954, DOI: 10.1016/0198-8859(90)90027-m.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntigen-Presenting CellsEndothelium, VascularHLA-D AntigensHumansImmunity, CellularInflammationLymphocyte ActivationConceptsCell-mediated immune reactionsT cellsImmune reactionsEndothelial cellsFunctional T cell activationClass II major histocompatibility complex moleculesImmune accessory functionAntigen-specific CD4Helper T cellsAntigen presenting cellsDevelopment of inflammationMajor histocompatibility complex moleculesBlood-derived leukocytesImmune accessory cellsCell typesT cell activationHistocompatibility complex moleculesVascular endothelial cellsSpecific CD4Inflammatory infiltrateVascular responsesPresenting cellsForeign antigensVascular endotheliumCostimulatory signals
1985
Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones.
Umetsu DT, Pober JS, Jabara HH, Fiers W, Yunis EJ, Burakoff SJ, Reiss CS, Geha RS. Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones. Journal Of Clinical Investigation 1985, 76: 254-260. PMID: 3160726, PMCID: PMC423759, DOI: 10.1172/jci111955.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsTetanus toxoidProliferative responseClassical antigen-presenting cellsAntigen-specific proliferative responsesAntigen-specific T cell clonesHLA-DR antigensHelper T cellsTetanus toxoid antigenT cell proliferationT cell clonesHuman dermal fibroblastsPresent tetanus toxoidMonoclonal antibody OKM1Cultured human dermal fibroblastsDermal fibroblastsLeu-M1DR expressionHLA-DRUbiquitous cell typeAntigen presentationT cellsToxoid antigenSephadex G10 columnImmune interferon
1984
Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens
Pober JS, Gimbrone MA, Collins T, Cotran RS, Ault KA, Fiers W, Krensky AM, Clayberger C, Reiss C, Burakoff SJ. Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens. Immunobiology 1984, 168: 483-494. PMID: 6397428, DOI: 10.1016/s0171-2985(84)80132-1.Peer-Reviewed Original ResearchConceptsClass II antigensVascular endothelial cellsMajor histocompatibility complexII antigensT cellsClass II moleculesHuman vascular endothelial cellsActivated T cellsEndothelial cellsStromal cellsImmune interferonT lymphocytesAntigen-specific T cellsPeripheral blood T lymphocytesClass IHelper T cell clonesImmune accessory functionNon-MHC antigensWithdrawal of interferonClass II major histocompatibility complexCultured human vascular endothelial cellsT cell responsesVascular smooth muscle cellsBlood T lymphocytesHuman class II antigens