2019
Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells
Baltazar T, Merola J, Catarino C, Xie C, Kirkiles-Smith N, Lee V, Hotta S, Dai G, Xu X, Ferreira FC, Saltzman WM, Pober JS, Karande P. Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells. Tissue Engineering Part A 2019, 26: 227-238. PMID: 31672103, PMCID: PMC7476394, DOI: 10.1089/ten.tea.2019.0201.Peer-Reviewed Original ResearchConceptsSkin graftsHuman endothelial colony-forming cellsEndothelial cellsHuman endothelial cellsHuman skin graftsEndothelial colony-forming cellsPlacental pericytesGraft survivalCutaneous ulcersAllogeneic cellsHuman foreskin keratinocytesMouse microvesselsImmunodeficient miceHuman pericytesGraftColony-forming cellsVascular structuresWound bedForeskin keratinocytesEpidermal maturationPericytesHuman placental pericytesHuman keratinocytesKeratinocytesType I
1989
Vascular endothelial cells enhance T cell responses by markedly augmenting IL-2 concentrations
Guinan E, Smith B, Doukas J, Miller R, Pober J. Vascular endothelial cells enhance T cell responses by markedly augmenting IL-2 concentrations. Cellular Immunology 1989, 118: 166-177. PMID: 2562928, DOI: 10.1016/0008-8749(89)90366-3.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsIL-2 concentrationsPolyclonal mitogen phytohemagglutininT cell responsesEndothelial cellsBlood monocytesUnfractionated peripheral blood mononuclear cellsCell responsesPrimary allogeneic responseSuboptimal PHA concentrationsExogenous IL-2Blood mononuclear cellsT cell populationsRecombinant IL-1Cultured human endothelial cellsDermal fibroblastsIL-2 synthesisVascular endothelial cellsQuantity of antigenHuman endothelial cellsAllogeneic responseMitogen phytohemagglutininMononuclear cellsIL-2Presence of EC
1987
Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts.
Kurt-Jones EA, Fiers W, Pober JS. Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts. The Journal Of Immunology 1987, 139: 2317-24. PMID: 3116078, DOI: 10.4049/jimmunol.139.7.2317.Peer-Reviewed Original Research
1986
Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon.
Leung DY, Collins T, Lapierre LA, Geha RS, Pober JS. Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. Journal Of Clinical Investigation 1986, 77: 1428-1435. PMID: 3084559, PMCID: PMC424542, DOI: 10.1172/jci112454.Peer-Reviewed Original ResearchConceptsAcute Kawasaki syndromeKawasaki syndromeImmunoglobulin M antibodiesGamma-IFNVein endothelial cellsM antibodiesEndothelial cellsT cellsKS seraGamma interferonClass II major histocompatibility complex antigen expressionMajor histocompatibility complex antigen expressionComplement-dependent cytotoxic activityAnti-endothelial cell antibodiesHUVE cellsHuman dermal fibroblastsHuman saphenous vein smooth muscle cellsSaphenous vein smooth muscle cellsMarked immune activationSecrete gamma interferonSecretion of lymphokinesEndothelial cell antigensAge-matched controlsVein smooth muscle cellsActivated T cellsINDUCIBLE EXPRESSION OF CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND THE IMMUNOGENICITY OF VASCULAR ENDOTHELIUM
POBER J, COLLINS T, GIMBRONE M, LIBBY P, REISS C. INDUCIBLE EXPRESSION OF CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND THE IMMUNOGENICITY OF VASCULAR ENDOTHELIUM. Transplantation 1986, 41: 141-146. PMID: 2935977, DOI: 10.1097/00007890-198602000-00001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRecombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.
Collins T, Lapierre LA, Fiers W, Strominger JL, Pober JS. Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 446-450. PMID: 3455781, PMCID: PMC322876, DOI: 10.1073/pnas.83.2.446.Peer-Reviewed Original ResearchConceptsClass II MHC antigensTumor necrosis factorClass I major histocompatibility complexI major histocompatibility complexRecombinant human tumor necrosis factorMajor histocompatibility complexHuman tumor necrosis factorHuman endothelial cellsMHC antigensSurface expressionNecrosis factorMRNA levelsHuman dermal fibroblastsEndothelial cellsClass IPresence of TNFCultured human endothelial cellsType I interferonVascular endothelial cellsMHC gene expressionMHC gene regulationDermal fibroblastsImmunoregulatory moleculesB antigensI interferon
1985
Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones.
Umetsu DT, Pober JS, Jabara HH, Fiers W, Yunis EJ, Burakoff SJ, Reiss CS, Geha RS. Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones. Journal Of Clinical Investigation 1985, 76: 254-260. PMID: 3160726, PMCID: PMC423759, DOI: 10.1172/jci111955.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsTetanus toxoidProliferative responseClassical antigen-presenting cellsAntigen-specific proliferative responsesAntigen-specific T cell clonesHLA-DR antigensHelper T cellsTetanus toxoid antigenT cell proliferationT cell clonesHuman dermal fibroblastsPresent tetanus toxoidMonoclonal antibody OKM1Cultured human dermal fibroblastsDermal fibroblastsLeu-M1DR expressionHLA-DRUbiquitous cell typeAntigen presentationT cellsToxoid antigenSephadex G10 columnImmune interferon
1984
Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules.
Collins T, Krensky AM, Clayberger C, Fiers W, Gimbrone MA, Burakoff SJ, Pober JS. Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules. The Journal Of Immunology 1984, 133: 1878-84. PMID: 6432903, DOI: 10.4049/jimmunol.133.4.1878.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigens, SurfaceBinding Sites, AntibodyCell CommunicationCytotoxicity, ImmunologicEndotheliumFibroblastsHistocompatibility Antigens Class IIHLA-DR AntigensHumansIndiumInterferon-gammaLymphocyte Function-Associated Antigen-1RadioisotopesT-LymphocytesT-Lymphocytes, CytotoxicUmbilical VeinsConceptsCytolytic T lymphocytesVascular endotheliumCultured human vascular endotheliumLFA-1LFA-2Human cytolytic T lymphocytesHuman CTL linesT lymphocyte interactionsCell typesSame CTL clonesImportant target cellsTarget cell structuresHuman vascular endotheliumLymphoid targetsHost diseaseAllograft rejectionImmune injuryHLA-DRCell surface moleculesCTL linesCTL clonesT lymphocytesLymphocyte interactionsTarget cell typeLFA-3
1983
Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon
Pober J, Collins T, Gimbrone M, Cotran R, Gitlin J, Fiers W, Clayberger C, Krensky A, Burakoff S, Reiss C. Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature 1983, 305: 726-729. PMID: 6415484, DOI: 10.1038/305726a0.Peer-Reviewed Original ResearchConceptsCytolytic T lymphocytesRecombinant immune interferonIa antigensT cellsIa expressionAlloreactive cytolytic T lymphocytesClass II major histocompatibility complex antigensT-lymphocyte-mediated responsesImmune interferonEndothelial cellsMajor histocompatibility complex antigensForeign class IHistocompatibility complex antigensHuman vascular endothelialHuman umbilical vein endothelial cellsHUVE cellsCapillary endothelial cellsUmbilical vein endothelial cellsHuman T cellsImmunological cell typesAllograft rejectionVein endothelial cellsOrgan graftsT lymphocytesComplex antigens