2021
Cardiac allograft vasculopathy: current review and future research directions
Pober JS, Chih S, Kobashigawa J, Madsen JC, Tellides G. Cardiac allograft vasculopathy: current review and future research directions. Cardiovascular Research 2021, 117: 2624-2638. PMID: 34343276, PMCID: PMC8783389, DOI: 10.1093/cvr/cvab259.Peer-Reviewed Original ResearchConceptsCardiac allograft vasculopathyAllograft vasculopathyImmune-mediated vasculopathyLate graft lossGraft lossCardiac transplantationOrgan graftsTransplanted heartsCurrent therapiesVascular remodellingVasculopathyMajor causeCurrent reviewRemodellingTransplantationPathogenesisGraftTherapyPerfusionIncidenceDiagnosisVasculature
2019
ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy
Jane-Wit D, Fang C, Liu L, Qin L, Li G, Tellides G, Pober J. ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy. The Journal Of Heart And Lung Transplantation 2019, 38: s249. DOI: 10.1016/j.healun.2019.01.618.Peer-Reviewed Original ResearchCardiac allograft vasculopathyAllograft vasculopathyHumanized mouse modelMembrane attack complexNF-κB-inducing kinaseTransplant biopsiesMouse modelEC activationHuman coronary artery segmentsEndothelial cellsAntibody-mediated rejectionTransplant organ rejectionCoronary artery segmentsHuman lymphoid cellsVascular inflammationOrgan rejectionArtery segmentsPharmacologic alterationsVasculopathyLymphoid cellsNF-kBClinical relevance
2013
IDENTIFICATION OF A NOVEL COMPLEMENT–INDUCED SIGNALING PATHWAY IN ENDOTHELIAL CELLS THAT IS IMPLICATED IN THE DEVELOPMENT OF CORONARY GRAFT VASCULOPATHY
Jane–Wit D, Pober J, Tellides G. IDENTIFICATION OF A NOVEL COMPLEMENT–INDUCED SIGNALING PATHWAY IN ENDOTHELIAL CELLS THAT IS IMPLICATED IN THE DEVELOPMENT OF CORONARY GRAFT VASCULOPATHY. Journal Of The American College Of Cardiology 2013, 61: e2109. DOI: 10.1016/s0735-1097(13)62109-9.Peer-Reviewed Original Research