2020
Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations
Wang K, Zhang H, He Y, Jiang Q, Tanaka Y, Park IH, Pober JS, Min W, Zhou HJ. Mural Cell-Specific Deletion of Cerebral Cavernous Malformation 3 in the Brain Induces Cerebral Cavernous Malformations. Arteriosclerosis Thrombosis And Vascular Biology 2020, 40: 2171-2186. PMID: 32640906, DOI: 10.1161/atvbaha.120.314586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsBrainCell CommunicationCell MovementCells, CulturedCoculture TechniquesEndothelial CellsFemaleFocal AdhesionsGene DeletionGenetic Predisposition to DiseaseHemangioma, Cavernous, Central Nervous SystemHumansMaleMembrane ProteinsMice, KnockoutMicrovesselsMyocytes, Smooth MusclePaxillinPericytesPhenotypeProtein StabilityProto-Oncogene ProteinsSignal TransductionConceptsCerebral cavernous malformationsBrain mural cellsCCM lesionsMural cellsCavernous malformationsSevere brain hemorrhageCCM pathogenesisSmooth muscle cellsWeeks of ageCell-specific deletionMural cell coverageBrain pericytesBrain hemorrhageNeonatal stageBrain vasculatureLesionsEntire brainMuscle cellsCerebral cavernous malformation 3Endothelial cellsMicePericytesSpecific deletionAdhesion formationPathogenesis
2011
Cellular Delivery for Vascularization of Engineered Tissues: Reduction of Contraction by Mural Cells
Andrejecsk J, Trivellas M, Maier C, Pober J, Saltzman W. Cellular Delivery for Vascularization of Engineered Tissues: Reduction of Contraction by Mural Cells. 2011, 1: 1-2. DOI: 10.1109/nebc.2011.5778700.Peer-Reviewed Original ResearchEndothelial cellsReduction of contractionHuman endothelial cellsImmunodeficient miceHuman pericytesEarly perfusionGel contractionMural cellsVascular structuresVascular stabilityPericytesMicrovesselsTissueVascular networkVascularizationCellsContractionFunctional vascular networkDeliverySimultaneous deliveryTransplantationPerfusionMice
2009
Engineered Molecular Delivery for Control and Enhancement of Transplanted Endothelial Cell Fate in Tissue Engineering
Jay S, Shepherd B, Andrejecsk J, Kyriakides T, Pober J, Saltzman W. Engineered Molecular Delivery for Control and Enhancement of Transplanted Endothelial Cell Fate in Tissue Engineering. 2009, 1: 1-2. DOI: 10.1109/nebc.2009.4967788.Peer-Reviewed Original ResearchTissue engineeringAdvanced tissue engineeringMultifunctional hydrogelsTissue constructsFunctional microvascular networksTransplantation of ECsEndothelial cell fateBiomaterial strategiesAlginate microparticlesVascular endothelial growth factorEndothelial cellsEngineeringHydrogelsCell fateGrowth factorSustained releaseProtein 1Mural cellsMolecular deliveryMonocyte chemoattractant protein-1Cell populationsProtein therapeuticsProtein matrixAngiogenic growth factorsProtein delivery