1990
IFN-gamma enhances endothelial activation induced by tumor necrosis factor but not IL-1.
Doukas J, Pober JS. IFN-gamma enhances endothelial activation induced by tumor necrosis factor but not IL-1. The Journal Of Immunology 1990, 145: 1727-33. PMID: 1697308, DOI: 10.4049/jimmunol.145.6.1727.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell Adhesion MoleculesDrug SynergismE-SelectinEndothelium, VascularFluorescent Antibody TechniqueGene ExpressionHistocompatibility Antigens Class IHumansIn Vitro TechniquesIntercellular Adhesion Molecule-1Interferon-gammaInterleukin-1Recombinant ProteinsRNA, MessengerTumor Necrosis Factor-alphaConceptsEndothelial leukocyte adhesion molecule-1ELAM-1 expressionIL-1 betaIFN-gammaIL-1Endothelial cellsEC activationIL-1 beta responseIntercellular adhesion molecule-1 expressionAdhesion molecule-1 expressionMHC Ag expressionLeukocyte adhesion molecule-1Treatment of ECICAM-1 expressionMolecule-1 expressionClass I MHC moleculesTumor necrosis factorAdhesion molecule-1ICAM-1 mRNAClass I MHCI MHC moleculesIFN-gamma effectELAM-1 mRNACultured endothelial cellsIncrease TNFCytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE.
Rollins BJ, Yoshimura T, Leonard EJ, Pober JS. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. American Journal Of Pathology 1990, 136: 1229-33. PMID: 2113354, PMCID: PMC1877579.Peer-Reviewed Original ResearchConceptsMCP-1/JEIL-1 betaEndothelial cellsMonocyte chemoattractantMonocyte chemoattractant MCP-1Tumor necrosis factorChemoattractant MCP-1Accumulation of monocytesSites of inflammationMonocyte chemoattractant activityHours of treatmentHuman endothelial cellsInflammatory mediatorsMCP-1Necrosis factorIFN-gammaChemoattractant activityJE proteinChemoattractantCellsBetaHoursInducible expressionMRNALesser extent
1987
Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species.
Pober JS, Lapierre LA, Stolpen AH, Brock TA, Springer TA, Fiers W, Bevilacqua MP, Mendrick DL, Gimbrone MA. Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. The Journal Of Immunology 1987, 138: 3319-24. PMID: 3494766, DOI: 10.4049/jimmunol.138.10.3319.Peer-Reviewed Original ResearchConceptsTumor necrosis factorAction of lymphotoxinCultured human endothelial cellsHuman endothelial cellsIL-1 speciesPhorbol ester pretreatmentNecrosis factorLeukocyte adhesionEndothelial cellsRecombinant human tumor necrosis factorSecretion of lymphotoxinExpression of HLAIL-1 betaIL-1 alphaInhibited inductionHuman tumor necrosis factorActivated T cellsPhorbol esterInflammatory leukocyte adhesionRecombinant human lymphotoxinInflammatory cellsT cellsIL-1Hr pretreatmentIFN-gammaEffects of Tumour Necrosis Factor and Related Cytokines on Vascular Endothelial Cells
Pober J. Effects of Tumour Necrosis Factor and Related Cytokines on Vascular Endothelial Cells. Novartis Foundation Symposia 1987, 131: 170-191. PMID: 3330009, DOI: 10.1002/9780470513521.ch12.Peer-Reviewed Original ResearchConceptsIL-1 betaHuman endothelial cellsIL-1 alphaRelated cytokinesVascular endothelial cellsEndothelial cellsNecrosis factorEndothelial leucocyte adhesion moleculeIntercellular adhesion molecule-1Tumor necrosis factorInterleukin-1 betaAdhesion molecule-1Endothelial cell activationInterleukin-1 alphaCultured human endothelial cellsPhorbol esterEffects of TNFRecombinant human TNFCytoplasmic calcium concentrationIL-1 speciesMechanism of actionHEC adhesivenessInflammatory leucocytesCell surface expressionProtein kinase C pathway