1986
Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon.
Leung DY, Collins T, Lapierre LA, Geha RS, Pober JS. Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon. Journal Of Clinical Investigation 1986, 77: 1428-1435. PMID: 3084559, PMCID: PMC424542, DOI: 10.1172/jci112454.Peer-Reviewed Original ResearchConceptsAcute Kawasaki syndromeKawasaki syndromeImmunoglobulin M antibodiesGamma-IFNVein endothelial cellsM antibodiesEndothelial cellsT cellsKS seraGamma interferonClass II major histocompatibility complex antigen expressionMajor histocompatibility complex antigen expressionComplement-dependent cytotoxic activityAnti-endothelial cell antibodiesHUVE cellsHuman dermal fibroblastsHuman saphenous vein smooth muscle cellsSaphenous vein smooth muscle cellsMarked immune activationSecrete gamma interferonSecretion of lymphokinesEndothelial cell antigensAge-matched controlsVein smooth muscle cellsActivated T cellsRecombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.
Collins T, Lapierre LA, Fiers W, Strominger JL, Pober JS. Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 446-450. PMID: 3455781, PMCID: PMC322876, DOI: 10.1073/pnas.83.2.446.Peer-Reviewed Original ResearchConceptsClass II MHC antigensTumor necrosis factorClass I major histocompatibility complexI major histocompatibility complexRecombinant human tumor necrosis factorMajor histocompatibility complexHuman tumor necrosis factorHuman endothelial cellsMHC antigensSurface expressionNecrosis factorMRNA levelsHuman dermal fibroblastsEndothelial cellsClass IPresence of TNFCultured human endothelial cellsType I interferonVascular endothelial cellsMHC gene expressionMHC gene regulationDermal fibroblastsImmunoregulatory moleculesB antigensI interferon
1985
Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones.
Umetsu DT, Pober JS, Jabara HH, Fiers W, Yunis EJ, Burakoff SJ, Reiss CS, Geha RS. Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones. Journal Of Clinical Investigation 1985, 76: 254-260. PMID: 3160726, PMCID: PMC423759, DOI: 10.1172/jci111955.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsTetanus toxoidProliferative responseClassical antigen-presenting cellsAntigen-specific proliferative responsesAntigen-specific T cell clonesHLA-DR antigensHelper T cellsTetanus toxoid antigenT cell proliferationT cell clonesHuman dermal fibroblastsPresent tetanus toxoidMonoclonal antibody OKM1Cultured human dermal fibroblastsDermal fibroblastsLeu-M1DR expressionHLA-DRUbiquitous cell typeAntigen presentationT cellsToxoid antigenSephadex G10 columnImmune interferon