2005
Dynamic Partitioning into Lipid Rafts Controls the Endo-Exocytic Cycle of the αL/β2 Integrin, LFA-1, during Leukocyte Chemotaxis
Fabbri M, Di Meglio S, Gagliani MC, Consonni E, Molteni R, Bender JR, Tacchetti C, Pardi R. Dynamic Partitioning into Lipid Rafts Controls the Endo-Exocytic Cycle of the αL/β2 Integrin, LFA-1, during Leukocyte Chemotaxis. Molecular Biology Of The Cell 2005, 16: 5793-5803. PMID: 16207819, PMCID: PMC1289422, DOI: 10.1091/mbc.e05-05-0413.Peer-Reviewed Original ResearchConceptsDetergent-resistant membranesInternalized receptorsLate endosomal pathwayCholesterol-sequestering agentRab11 mutantDRM associationPolarized recyclingCell rearCell frontPlasma membraneChemoattractant stimulationEndocytic compartmentsEndosomal pathwayAdhesion receptorsCell migrationNew protrusionsIntegrinsLFA-1Dynamic redistributionMutantsLamellipodiaAdhesive interactionsPrimary neutrophilsIntracellular accumulationΒ2 integrins
1992
Regulatory mechanisms in leukocyte adhesion: flexible receptors for sophisticated travelers
Pardi R, Inverardi L, Bender J. Regulatory mechanisms in leukocyte adhesion: flexible receptors for sophisticated travelers. Trends In Immunology 1992, 13: 224-230. PMID: 1304726, DOI: 10.1016/0167-5699(92)90159-5.Peer-Reviewed Original Research